The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders
The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders
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DOI：
10.1080/13547500902783747
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发表时间：
2009-01-01
期刊：
影响因子：
2.6
通讯作者：
Kingston, H. M. Skip
中科院分区：
文献类型：
--
作者：
Faber, Scott;Zinn, Gregory M.;Kingston, H. M. Skip
自闭症谱系障碍（asd）儿童缺锌、铜中毒和低锌/低铜的频率可能表明金属硫蛋白系统功能的下降。对230名患有自闭症、广泛性发育障碍（nos）和阿斯伯格综合征的儿童进行了血浆锌、血清铜和锌/铜的回顾性分析。整个队列的平均锌水平为77.2 g dl-1，平均铜水平为131.5 g dl-1，平均Zn/Cu为0.608，低于最低2.5%健康儿童的0.7临界值。血浆锌/血清铜比值可能是自闭症儿童重金属（尤其是汞）毒性的生物标志物。
The frequency of zinc deficiency, copper toxicity and low zinc/copper in children with autism spectrum disorders (ASDs) may indicate decrement in metallothionein system functioning. A retrospective review of plasma zinc, serum copper and zinc/copper was performed on data from 230 children with autistic disorder, pervasive developmental disorder-NOS and Asperger's syndrome. The entire cohort's mean zinc level was 77.2 g dl-1, mean copper level was 131.5 g dl-1, and mean Zn/Cu was 0.608, which was below the 0.7 cut-off of the lowest 2.5% of healthy children. The plasma zinc/serum copper ratio may be a biomarker of heavy metal, particularly mercury, toxicity in children with ASDs.