Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex.
Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex.
复制标题
一氧化氮合酶的抑制不会改变小猫视觉皮层的眼部优势转移。
DOI：
10.1113/jphysiol.1996.sp021509
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Sessa,WC
中科院分区：
文献类型：
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作者：
Reid,SN;Daw,NW;Czepita,D;Flavin,HJ;Sessa,WC
1.由于一氧化氮被认为是海马可塑性的反馈因子，我们测试了它是否也可能是猫视觉皮层感觉依赖可塑性的反馈因子。2.单眼剥夺的影响进行了比较，8个半球与一氧化氮合酶抑制剂的输液，和8个控制半球与非活性异构体的输液，或没有输液。虽然一氧化氮合酶的活性显着降低，眼优势直方图没有实质性的差异，在两组动物。我们的结论是，视觉皮层中感觉依赖性可塑性的反馈因素可能是一氧化氮以外的其他因素。
1. Since nitric oxide has been proposed as a feedback factor in plasticity in the hippocampus, we tested whether it might also be a feedback factor in sensory‐dependent plasticity in the cat visual cortex. 2. The effects of monocular deprivation were compared between eight hemispheres with infusion of a nitric oxide synthase inhibitor, and eight control hemispheres with either infusion of the inactive isomer, or no infusion. Although nitric oxide synthase activity was reduced significantly, the ocular dominance histograms were not substantially different in the two groups of animals. We conclude that the feedback factor for sensory‐dependent plasticity in the visual cortex is likely to be some factor other than nitric oxide.