REASSESSMENT OF CRITERIA FOR THE SELECTION OF PERFLUOROCHEMICALS FOR 2ND-GENERATION BLOOD SUBSTITUTES - ANALYSIS OF STRUCTURE PROPERTY RELATIONSHIPS
REASSESSMENT OF CRITERIA FOR THE SELECTION OF PERFLUOROCHEMICALS FOR 2ND-GENERATION BLOOD SUBSTITUTES - ANALYSIS OF STRUCTURE PROPERTY RELATIONSHIPS
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DOI：
10.1111/j.1525-1594.1984.tb04243.x
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发表时间：
1984-01-01
影响因子：
2.4
通讯作者：
RIESS, JG
中科院分区：
文献类型：
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作者：
RIESS, JG
根据目前可获得的大量数据，重点讨论了在第二代血液代用品中用作氧载体的全氟化学品的选择标准。强调需要纯的、明确定义的、可重复的、工业上可行的全氟化学品，以达到其在医学上使用所需的可靠性程度。特别注意的是排泄率与乳剂稳定性的逆关系及其对分子量的强烈依赖。可接受分子量范围为460-520。氧溶解能力，流变学特性和血管内持久性也进行了讨论。重申了对标准方法和实验方案的需要。评价前景的目的尤其在于减轻目前的某些限制。
The criteria for the selection of perfluorochemicals destined to serve as oxygen carriers in second‐generation blood substitutes are critically discussed in light of the presently available body of data. The need for pure, well‐defined, reproducible, industrially feasible perfluorochemicals, in order to attain the degree of reliability desirable for their use in medicine, is stressed. Particular attention is given to the inverse excretion rate versus emulsion stability relationship and to its sharp dependence on molecular weight. The range of acceptable molecular weights is established as 460–520. Oxygen‐dissolving capacity, rheologic characteristics, and intravascular persistence are also discussed. The need for standard methodology and experimental protocols is reaffirmed. Perspectives are evaluated, in particular, with the aim of easing certain of the present limitations.