The potential role of epigenetic modifications in the heritability of multiple sclerosis
The potential role of epigenetic modifications in the heritability of multiple sclerosis
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DOI：
10.1177/1352458514520911
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发表时间：
2014-02
影响因子：
5.8
通讯作者：
Yuan Zhou;S. Simpson;A. Holloway;J. Charlesworth;I. van der Mei;B. Taylor
中科院分区：
文献类型：
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作者：
Yuan Zhou;S. Simpson;A. Holloway;J. Charlesworth;I. van der Mei;B. Taylor
现在已经确定遗传和环境因素都有助于多发性硬化症（MS）的发展并相互作用。然而，目前描述的因果遗传变异不能解释MS的大部分遗传性，导致“遗传性缺失”。表观遗传机制，主要包括DNA甲基化，组蛋白修饰和microRNA介导的转录后基因沉默，可能是这种缺失的遗传性的重要组成部分。由于MS的发展是一个动态的过程，可能从炎症开始，然后脱髓鞘，髓鞘再生和神经变性，我们已经审查了MS发病机制的这些方面的动态表观遗传变化，并描述了环境风险因素如何与表观遗传变化相互作用，以体现在疾病中。
It is now well established that both genetic and environmental factors contribute to and interact in the development of multiple sclerosis (MS). However, the currently described causal genetic variants do not explain the majority of the heritability of MS, resulting in ‘missing heritability’. Epigenetic mechanisms, which principally include DNA methylation, histone modifications and microRNA-mediated post-transcriptional gene silencing, may contribute a significant component of this missing heritability. As the development of MS is a dynamic process potentially starting with inflammation, then demyelination, remyelination and neurodegeneration, we have reviewed the dynamic epigenetic changes in these aspects of MS pathogenesis and describe how environmental risk factors may interact with epigenetic changes to manifest in disease.