Distinct encoding of decision confidence in human medial prefrontal cortex
Distinct encoding of decision confidence in human medial prefrontal cortex
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DOI：
10.1073/pnas.1800795115
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发表时间：
2018-06-05
影响因子：
11.1
通讯作者：
Fleming, Stephen M.
中科院分区：
文献类型：
--
作者：
Bang, Dan;Fleming, Stephen M.
我们对选择的信心和与选择有关的证据似乎是不可分割的。然而，一个新兴的计算共识认为，大脑应该保持这些量的自适应行为控制的单独估计。我们设计了一项心理物理任务，将感知决策的信心与感官证据的可靠性以及此类证据与选择边界的关系脱钩。使用人类功能性磁共振成像，我们发现内侧前额叶皮层中的一个区域，即膝周前扣带皮层（pgACC），跟踪预期的表现，一个决策信心的集合签名，而以前提出的编码决策信心的神经区域，而是跟踪感觉可靠性（后顶叶皮层和腹侧纹状体）或边界距离（前辅助运动区）。支持由pgACC编码的信息是中央的主观意义上的决策信心，我们表明，pgACC活动并不简单地与预期的性能协变，但也与内主题和主题之间的变化，在明确的信心估计。我们的研究与大脑保持选择依赖和选择独立的确定性估计的建议是一致的，并揭示了为什么功能失调的信心往往出现在前额叶损伤和/或退化。
Our confidence in a choice and the evidence pertaining to a choice appear to be inseparable. However, an emerging computational consensus holds that the brain shouldmaintain separate estimates of these quantities for adaptive behavioral control. We have devised a psychophysical task to decouple confidence in a perceptual decision from both the reliability of sensory evidence and the relation of such evidence with respect to a choice boundary. Using human fMRI, we found that an area in the medial prefrontal cortex, the perigenual anterior cingulate cortex (pgACC), tracked expected performance, an aggregate signature of decision confidence, whereas neural areas previously proposed to encode decision confidence instead tracked sensory reliability (posterior parietal cortex and ventral striatum) or boundary distance (presupplementary motor area). Supporting that information encoded by pgACC is central to a subjective sense of decision confidence, we show that pgACC activity does not simply covary with expected performance, but is also linked to within-subject and between-subject variation in explicit confidence estimates. Our study is consistent with the proposal that the brain maintains choice-dependent and choice-independent estimates of certainty, and sheds light on why dysfunctional confidence often emerges following prefrontal lesions and/or degeneration.