Oxidative Tandem Cyclization of Glycine Esters with Propargyl Alcohols
Oxidative Tandem Cyclization of Glycine Esters with Propargyl Alcohols
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DOI：
10.1021/acs.joc.3c00627
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发表时间：
2023-07-09
影响因子：
3.6
通讯作者：
Huo，Congde
中科院分区：
文献类型：
--
作者：
Sang，Tongzhi;Liang，Jia;Huo，Congde
A facile and efficient aerobic oxidative (4 + 2)-cyclization/aromatization/lactonization tandem reaction ofN-aryl glycine esters with propargyl alcohols to access quinoline-fused lactones is reported. The reaction can be extended to homopropargylic alcohols too. The transformation is straightforward to perform under mild conditions and scalable, and both reaction components are readily available.
