Extracellular matrix-based biomaterial scaffolds and the host response.
Extracellular matrix-based biomaterial scaffolds and the host response.
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DOI：
10.1016/j.biomaterials.2016.02.003
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发表时间：
2016-04
期刊：
影响因子：
14
通讯作者：
Grainger DW
中科院分区：
文献类型：
--
作者：
Aamodt JM;Grainger DW
细胞外基质（ECM）蛋白共同代表一类从收获的器官和组织纯化的天然衍生的蛋白质生物材料，其在组织工程和修复中的科学关注和效用日益增加。这种兴趣主要源于一个基本上未经证实的概念，即作为天然组织衍生基质的加工ECM生物材料比纯合成生物材料更好地与宿主组织整合。几乎每一种组织类型都被脱细胞化和加工，以重新用作组织衍生的ECM蛋白植入物和支架。然而，迄今为止，对于定义最佳构成脱细胞生物材料的ECM组合物或来源存在很少的共识，所述脱细胞生物材料可以更好地愈合、与宿主组织整合并避免异物反应（FBR）。根据惯例，用于评估生物材料植入物中ECM性能的参数是任意的，并且是特定于上下文的。很少有来自不同来源的ECM植入物的体内宿主反应的比较。这篇综述讨论了目前ECM衍生生物材料的表征方法，包括来自不同来源的ECM材料成分之间的关系，作为植入物的性能和宿主组织反应。相关的临床前体内模型进行比较沿着与其相关的优点和局限性，并讨论了用于定义材料集成和生物相容性的各种指标的当前状态。这些ECM衍生生物材料作为独立植入基质和器械的常用应用与宿主组织反应进行了比较。
Extracellular matrix (ECM) proteins collectively represent a class of naturally derived proteinaceous biomaterials purified from harvested organs and tissues with increasing scientific focus and utility in tissue engineering and repair. This interest stems predominantly from the largely unproven concept that processed ECM biomaterials as natural tissue-derived matrices better integrate with host tissue than purely synthetic biomaterials. Nearly every tissue type has been decellularized and processed for re-use as tissue-derived ECM protein implants and scaffolds. To date, however, little consensus exists for defining ECM compositions or sources that best constitute decellularized biomaterials that might better heal, integrate with host tissues and avoid the foreign body response (FBR). Metrics used to assess ECM performance in biomaterial implants are arbitrary and contextually specific by convention. Few comparisons for in vivo host responses to ECM implants from different sources are published. This review discusses current ECM-derived biomaterials characterization methods including relationships between ECM material compositions from different sources, properties and host tissue response as implants. Relevant preclinical in vivo models are compared along with their associated advantages and limitations, and the current state of various metrics used to define material integration and biocompatibility are discussed. Commonly applied applications of these ECM-derived biomaterials as stand-alone implanted matrices and devices are compared with respect to host tissue responses.