Recommendations for Advancing Genome to Phenome Research in Non-Model Organisms
Recommendations for Advancing Genome to Phenome Research in Non-Model Organisms
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DOI：
10.1093/icb/icaa059
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发表时间：
2020-08-01
影响因子：
2.6
通讯作者：
Schmidt, Carl
中科院分区：
文献类型：
--
作者：
Burnett, Karen G.;Durica, David S.;Schmidt, Carl
2020年SICB全社会研讨会“从基因组到表型组的桥梁：分子，方法和模型”汇集了不同的科学家群体，讨论将表型可塑性与基因组，表观基因组和蛋白质组水平的变化联系起来的最新进展，同时探索变异和物种形成之间的界限。在一个后续讲习班上，与会者被要求评价现行办法的优点和缺点，查明阻碍其进展的共同障碍，并概述克服这些障碍所需的资源。讨论小组普遍认识到目前基因组到现象组研究缺乏任何总体理论框架，因此，呼吁重新强调概念模型的发展以及创建和测试这些模型所需的跨学科合作。与会者还认识到，迫切需要新的和改进的分子和生物信息学方法来帮助描述跨系统发育的功能/表型。此外，像所有的科学努力一样，基因组到现象组研究的进展将通过改进科学教育和工作组内部和工作组之间的交流而得到加强。
The 2020 SICB Society-wide Symposium "Building Bridges from Genome to Phenome: Molecules, Methods and Models" brought together a diverse group of scientists to discuss recent progress in linking phenotype plasticity to changes at the level of the genome, epigenome, and proteome, while exploring the boundaries between variation and speciation. In a follow-up workshop, participants were asked to assess strengths and weaknesses of current approaches, to identify common barriers inhibiting their progress, and to outline the resources needed to overcome those barriers. Discussion groups generally recognized the absence of any overarching theoretical framework underlying current genome to phenome research and, therefore, called for a new emphasis on the development of conceptual models as well as the interdisciplinary collaborations needed to create and test those models. Participants also recognized a critical need for new and improved molecular and bioinformatic approaches to assist in describing function/phenotypes across phylogeny. Additionally, like all scientific endeavors, progress in genome to phenome research will be enhanced by improvements in science education and communication both within and among working groups.