Real-time monitoring of radiofrequency ablation of rabbit liver by respiratory-gated quantitative temperature MRI
Real-time monitoring of radiofrequency ablation of rabbit liver by respiratory-gated quantitative temperature MRI
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DOI：
10.1002/jmri.20605
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发表时间：
2006-07-01
影响因子：
4.4
通讯作者：
Trillaud, Herve
中科院分区：
文献类型：
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作者：
Lepetit-Coiffe, Matthieu;Quesson, Bruno;Trillaud, Herve
目的：目的：探讨磁共振成像（MRI）测温技术在射频（RF）肝消融术中的可行性和准确性，并预测消融区的大小。材料与方法：在1.5T磁场下，采用质子共振频率（PRF）法，对6只自由呼吸的家兔肝脏进行MRI实时温度监测。通过组织学分析评估的消融区的大小与从MR热剂量（TD）图预测的或从消融后即刻以及术后第4天和第8天获得的常规T1加权（T1 w）、T2加权（T2 w）和T1 w钆（Gd）增强（T1 w-Gd）图像得出的消融区大小进行比较。即使在RF沉积期间，MR温度不确定性也保持在1-2摄氏度以下。与其他MR图像相比，TD图显示出更高的预测性和准确性，与第8天组织学证实的病变相比，最终消融区大小的平均预测精度约为1 mm。结论：在本临床前研究中，基于致死剂量阈值的定量温度MRI是可行的，并提供了消融区大小的精确指示。
Purpose: To evaluate the feasibility and precision of magnetic resonance imaging (MRI) thermometry for monitoring radiofrequency (RF) liver ablation in vivo and predicting the size of the ablation zone.Materials and Methods: At 1.5T, respirator-triggered real-time MR temperature mapping (the proton resonance frequency (PRF) method) was used to monitor RF ablation in rabbit liver (N = 6) under free breathing. The size of the ablation zones, as assessed by histological analyses, was compared with that predicted from MR thermal dose (TD) maps or derived from conventional T1-weighted (T1w), T2-weighted (T2w), and T1w gadolinium (Gd)-enhanced (T1w-Gd) images acquired immediately after the ablation, and on days 4 and 8 postprocedure.Results: MR temperature uncertainty remained under 1-2 degrees C even during RF deposition. The TD maps were shown to be more predictive and precise than the other MR images, with an average predictive precision for the final ablation zone size of about 1 mm as compared to the histologically proven lesion on day 8.Conclusion: Quantitative temperature MRI during RF ablation is feasible and offered a precise indication of the ablation zone size in this preclinical study based on the lethal dose threshold.