Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets
Oral administration of Lactobacillus delbrueckii during the suckling period improves intestinal integrity after weaning in piglets
复制标题
哺乳期口服德氏乳杆菌可改善仔猪断奶后的肠道完整性
DOI：
10.1016/j.jff.2019.103591
复制
发表时间：
2019-12-01
影响因子：
5.6
通讯作者：
Huang, Xingguo
中科院分区：
文献类型：
--
作者：
Li, Yinghui;Hou, Shuling;Huang, Xingguo
本研究旨在探讨哺乳期添加德氏乳杆菌（LAB）对仔猪肠道完整性的影响。益生菌LAB增加了最终体重，免疫球蛋白G和抗炎细胞因子的浓度，但在实验期间的任何阶段都将腹泻发病率降低了50%以上。实验组仔猪肠绒毛高度高于对照组。沿着LAB仔猪血清二胺氧化酶活性的降低，肠紧密连接蛋白的mRNA表达同时增加。我们的结论是，给予哺乳仔猪LAB可以刺激免疫反应，改善肠道形态和屏障功能，从而减轻腹泻并促进生长，重要的是，这些有益作用可以维持到断奶后4周。适当利用乳酸菌对新生儿有益于未来的肠道健康。
This study was conducted to explore the effect of administrated Lactobacillus delbrueckii (LAB) during the suckling period on future intestinal integrity of the host, using a piglet model. Probiotic LAB increased final body weight, concentrations of immunoglobulin G and anti-inflammatory cytokines, but reduced diarrhea incidence by over 50% during any phase of experimental period. The intestinal villus height of the LAB-treated piglets were greater than that in the control piglets. Along with lower activity of serum diamine oxidase in the LAB piglets, there was a concurrent increase in mRNA expression of intestinal tight junctions proteins. We conclude that LAB, given to suckling piglets, stimulates immune response and improves intestinal morphology and barrier function, thereby mitigating diarrhea and promoting growth, importantly, these beneficial effects could be maintained up to 4 weeks after weaning. A proper utilization of LAB to neonates would be beneficial to future intestinal health.