Massive pulmonary thromboembolism demonstrated at necropsy in Japanese psychiatric patients treated with neuroleptics including atypical antipsychotics
Massive pulmonary thromboembolism demonstrated at necropsy in Japanese psychiatric patients treated with neuroleptics including atypical antipsychotics
复制标题
DOI：
10.1253/circj.68.850
复制
发表时间：
2004-09-01
影响因子：
3.3
通讯作者：
Miyaoka, H
中科院分区：
文献类型：
--
作者：
Hamanaka, S;Kamijo, Y;Miyaoka, H
背景抗精神病药物可能增加肺血栓栓塞症（PTE）的风险，因此在日本一所大学医院的法律的医学部确定的突然意外死亡的尸检病例中调查了这种关联。方法和结果1，125例法医尸检记录对808名男性和317名女性患者进行调查，并进行Logistic回归分析，以探讨年龄、性别、体重指数（BMI）和抗精神病药物的使用与致死性PTE相关。在所有记录中，34例（3.0%; 14例男性，20例女性）指出使用抗精神病药物，28例（2.5%; 9例男性，19例女性）指出PTE是死亡原因。在死于PTE的28例受试者中，8例（29%）曾服用抗精神病药物，均为女性。女性和抗精神病药物的使用导致PTE死亡的风险显著增高，比值比分别为4.22（95%CI（0），1.82-9.78; p < 0.01）和10.49（95%CI，3.95-27.85; p < 0.01）。
Background There may be an increased risk of pulmonary thromboembolism (PTE) with antipsychotic drugs, so this association was investigated in autopsy cases of sudden unexpected death determined by the Department of Legal Medicine of a Japanese university hospital.Methods and Results Records of 1, 125 forensic autopsies (808 males, 317 females) performed during the study period for investigation of the cause of sudden unexpected death were reviewed and a logistic regression analysis was performed to explore whether age, gender, body mass index (BMI), and antipsychotic drug use were associated with fatal PTE. Among all records, 34 (3.0%; 14 males, 20 females) indicated the use of antipsychotic drugs and 28 (2.5%; 9 males, 19 females) indicated PTE as the cause of death. Of the 28 subjects who died from PTE, 8 had taken antipsychotic drugs (29%) and all were female. Female gender and antipsychotic drug use accounted for a significantly higher risk of PTE death with an odds ratio of 4.22 (95% confidence interval (0), 1.82-9.78; p < 0.01) and 10.49 (95% CI, 3.95-27.85; p < 0.01), respectively.Conclusions Japanese women taking antipsychotic drugs may be at particular risk for PTE.