Incorporation of the Living Heart Model into the 4D XCAT Phantom for Cardiac Imaging Research.
Incorporation of the Living Heart Model into the 4D XCAT Phantom for Cardiac Imaging Research.
复制标题
将活体心脏模型纳入 4D XCAT 体模，用于心脏成像研究。
DOI：
10.1109/trpms.2018.2823060
复制
发表时间：
2019
影响因子：
4.4
通讯作者：
Samei,Ehsan
中科院分区：
文献类型：
--
作者：
Segars,WPaul;Veress,AlexanderI;Sturgeon,GregoryM;Samei,Ehsan
4-D扩展心脏-躯干（XCAT）幻影为研究解剖和运动对医学图像的影响，特别是心脏运动的影响提供了一个有价值的工具。XCAT的一个限制是，它没有一个生理基础，现实地模拟心脏功能的变化。在本文中，我们将活体心脏项目开发的四室有限元（FE）活体心脏模型（LHM）纳入XCAT解剖。LHM代表了心脏FE模拟的最新技术，因为它能够准确地复制整个心脏的生物力学运动及其变化。我们创造了一系列新的4d幻影，能够模拟不同体型和体型的病人；心脏的位置、方向和动力学。虽然可以扩展到其他成像模式和技术，但我们的目标是使用fe增强的XCAT模型来研究计算机断层扫描评估冠状动脉疾病的最佳用途。增强的XCAT模型能够模拟真实的、可预测的、患者质量的4-D成像数据，从而使优化研究能够确定最有前途的系统或系统参数，以进行进一步的临床验证。
The 4-D extended cardiac-torso (XCAT) phantom has provided a valuable tool to study the effects of anatomy and motion on medical images, especially cardiac motion. One limitation of the XCAT was that it did not have a physiological basis which to realistically simulate variations in cardiac function. In this paper, we incorporate into the XCAT anatomy the four-chamber finite element (FE) living heart model (LHM) developed by the living heart project. The LHM represents the state of the art in cardiac FE simulation because of its ability to accurately replicate the biomechanical motion of the entire heart and its variations. We create a new series of 4-D phantoms capable of simulating patients with varying body sizes and shapes; cardiac positions, orientations, and dynamics. While extendable to other imaging modalities and technologies, our goal is to use the FE-enhanced XCAT models to investigate the optimal use of computed tomography for the evaluation of coronary artery disease. With the ability to simulate realistic, predictive, patient quality 4-D imaging data, the enhanced XCAT models will enable optimization studies to identify the most promising systems or system parameters for further clinical validation.