Tooth dimensions in hypodontia with a known PAX9 mutation
Tooth dimensions in hypodontia with a known PAX9 mutation
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DOI：
10.1016/j.archoralbio.2008.05.017
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发表时间：
2009-12-01
影响因子：
3
通讯作者：
Smith, R. N.
中科院分区：
文献类型：
--
作者：
Brook, A. H.;Elcock, C.;Smith, R. N.
目的：先天性缺牙是一个复杂的条件影响口腔发育的几个参数。这是第一个研究测量牙冠尺寸使用图像分析在一个家庭与缺牙在其中的突变已被确定，并将其与对照group.Methods和结果：研究模型获得了10个家庭成员从三代严重缺牙与错义突变PAX9和10个未受影响的，无关的控制。使用已建立的图像分析技术，由两名操作员从咬合（0）和颊（B）方面对所有牙齿（包括第一恒磨牙）进行三次数字成像，并对近远中（MDO和MDB）颊舌（BL）、面积（A）和周长（P）测量进行平均。计算组内相关系数（ICCC）以评估操作员内和操作员间的可靠性。然后使用双样本t检验将这些尺寸与对照组的尺寸进行比较。该技术的可靠性高（平均r > 0.95）。大多数牙齿类型在整个牙列显着小于在控制组的所有参数测量的家庭成员与缺牙。上侧切牙的显著性水平非常高（p < 0.0001），而犬齿和第一磨牙的差异较小。最大数量的显着差异被发现在BL和P，紧随其后的MD和A measurement.Conclusions：在受影响的家庭成员中记录的牙冠尺寸显着较小的PAX9突变的影响，不仅在先天性缺失的牙齿，但也在整个牙列较小的冠尺寸。(C)2008爱思唯尔有限公司保留所有权利。
Aim: Congenital absence of teeth is a complex condition affecting several parameters of oral development. This is the first study to measure tooth crown dimensions using image analysis in a family with hypodontia in whom the mutation has been identified, and compare them with a control group.Methods and results: Study models were obtained from 10 family members from three generations affected by severe hypodontia with a missense mutation in PAX9 and 10 unaffected, unrelated controls. Using established image analysis techniques all teeth up to and including the first permanent molars were digitally imaged by two operators from the occlusal (0) and buccal (B) aspects three times and an average made for the mesio-distal (MDO and MDB) bucco-lingual (BL), area (A) and perimeter (P) measurements. Intra-class correlation coefficients (ICCC) were calculated to assess intra- and inter-operator reliability. Two-sample t-tests were then used to compare these dimensions with those of the controls. Reliability of the technique was high (mean r > 0.95). The majority of tooth types throughout the dentition were significantly smaller in the family members with hypodontia than in the control group for all parameters measured. The levels of significance were very high for upper lateral incisors (p < 0.0001) whilst the canines and first molars were less different. The greatest number of significant differences were found in BL and P, closely followed by MD and A measurements.Conclusions: The significantly smaller tooth crown dimensions recorded in the affected family members show that the effect of the PAX9 mutation is seen not only in the congenitally missing teeth but also in smaller crown size throughout the dentition. (C) 2008 Elsevier Ltd. All rights reserved.