Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma
Inhibition of angiogenesis and induction of endothelial and tumor cell apoptosis by green tea in animal models of human high-grade non-Hodgkin's lymphoma
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DOI：
10.1038/sj.leu.2401854
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发表时间：
2000-08-01
期刊：
影响因子：
11.4
通讯作者：
Pruneri, G
中科院分区：
文献类型：
--
作者：
Bertolini, F;Fusetti, L;Pruneri, G
最近的报告表明，绿色茶消费可能会防止或延迟人类癌症的生长，可能是通过削弱肿瘤侵袭和/或通过抗血管生成作用。在NOD/SCID小鼠腹腔内移植人非霍奇金淋巴瘤（NHL）细胞系Namalwa，RAP 1-EIO和MS-苏丹，绿色茶防止50%的Namalwa肿瘤（P = 0.0017的对数秩），并显着抑制RAP 1-EIO和HS-苏丹肿瘤生长。值得注意的是，以最大耐受剂量的化疗药物环磷酰胺治疗无法预防Namalwa肿瘤的发生。在评估的三种模型中，与对照组相比，给予绿色茶的小鼠中凋亡内皮细胞和肿瘤细胞的频率显著增加。这些结果支持NHL的进一步试验，以评估绿色茶单独或与化疗联合是否可以延缓或预防疾病进展。
Recent reports suggest that green tea consumption may prevent or delay the growth of human cancer, possibly by impairing tumor invasion and/or by an anti-angiogenic effect. In NOD/SCID mice transplanted intraperitoneally with human non-Hodgkin's lymphoma (NHL) cell lines, Namalwa, RAP1-EIO and MS-Sultan, green tea prevented 50% of Namalwa tumors (P = 0.0017 by log-rank) and significantly inhibited RAP1-EIO and HS-Sultan tumor growth. Notably, treatment with the chemotherapy drug cyclophosphamide at the maximum tolerable dose was unable to prevent Namalwa tumor occurrence. In the three models evaluated, the frequency of apoptotic endothelial and tumor cells was significantly increased in mice given green tea compared to controls. These results support further trials in NHL to evaluate whether green tea, alone or in combination with chemotherapy, may delay or prevent disease progression.