Long-Term Histopathology of Intracranial Aneurysms after Endovascular Treatment with Coils
Long-Term Histopathology of Intracranial Aneurysms after Endovascular Treatment with Coils
复制标题
弹簧圈血管内治疗后颅内动脉瘤的长期组织病理学
DOI：
10.1177/15910199990050s143
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发表时间：
1999
影响因子：
1.7
通讯作者：
H. Masuda
中科院分区：
文献类型：
--
作者：
Y. Suda;K. Kikuchi;H. Shioya;K. Shindo;H. Nanjo;H. Masuda
我们描述了两例经血管内线圈栓塞成功治疗的颅内动脉瘤破裂患者的电镜检查结果。随访血管造影显示动脉瘤完全闭塞。这些患者分别死于肺炎和丘脑出血，分别在血管内治疗5个月和26个月后进行尸检。动脉瘤被密集的线圈填满，通过薄而透明的动脉瘤穹壁很容易识别。动脉瘤的孔完全闭塞，因此宏观上线圈不能通过孔直接看到。通过扫描电镜检查动脉瘤口是否有内皮化的迹象。在这两例病例中，通过动脉瘤口观察到良好再生内皮化的证据，与邻近母血管的内皮层相邻。这些超微结构结果表明，在血管内用线圈治疗后，动脉瘤通过再生内皮细胞的连续衬里与母动脉的管腔完全分离，并进一步表明动脉瘤有可能通过这种治疗方式永久治愈。据我们所知，这是第一个通过扫描电子显微镜证实动脉瘤颈线圈栓塞后管腔表面完全内皮化的人类报告。
We describe the results of electron microscopic examination in two patients with ruptured intracranial aneurysms who were successfully treated by endovascular coil embolization. The aneurysms were seen completely occluded on the follow-up angiograms. Autopsies of these patients were performed five and 26 months after endovascular treatment when they died of pneumonia and thalamic hemorrhage, respectively. The aneurysms were densely filled with the coils, which were readily identified through the thin and transparent wall of the aneurysmal dome. The orifice of the aneurysm was completely occluded so that macroscopically the coils were not directly visualized through the orifice. To examine any evidence of endothelialization across the orifice of the aneurysms, scanning electron microscopic examination was performed. In both cases, evidence of well regenerative endothelialization was observed across the aneurysmal orifice, being contiguous with the endothelial layer of the adjacent parent vessels. These ultrastructural findings indicate that the aneurysms are completely isolated from the lumen of the parent artery by a continuous lining of the regenerated endothelial cells following the endovascular treatment with coils, and further suggest that aneurysms have a potential of being cured permanently by this treatment modality. This is, to the best of our knowledge, the first report in humans verifying a complete endothelialization of the luminal surface at the aneurysmal neck after coil embolization, as evidenced by scanning electron microscopy.
影响因子：
4.1
作者：
GUGLIELMI, G;VINUELA, F;SEPETKA, I
通讯作者：
SEPETKA, I