Design considerations of silicon nanowire biosensors
Design considerations of silicon nanowire biosensors
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DOI：
10.1109/ted.2007.909059
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发表时间：
2007-12-01
影响因子：
3.1
通讯作者：
Alam, Muhammad A.
中科院分区：
文献类型：
--
作者：
Nair, Pradeep R.;Alam, Muhammad A.
基于硅纳米线的生物传感器有望实现对生物分子的高灵敏度动态无标记电检测。尽管有巨大的潜力和有前途的实验结果，生物分子的电感测的基本机制和NW传感器的设计考虑仍然知之甚少。在本文中，我们讨论的前景和挑战的生物分子检测使用硅纳米线生物传感器作为一个功能的设备参数，流体环境，电荷极性的生物分子，等等，并尽可能参考文献中的实验结果来支持非直观的预测。我们的研究结果表明，硅纳米生物传感器的设计是不平凡的，因此，只有仔细的优化支持数值模拟将确保最佳的传感器性能。
Biosensors based on silicon nanowires (Si-NWs) promise highly sensitive dynamic label-free electrical detection of biomolecules. Despite the tremendous potential and promising experimental results, the fundamental mechanism of electrical sensing of bioniolecules and the design considerations of NW sensors remain poorly understood. In this paper, we discuss the prospects and challenges of biomolecule detection using Si-NW biosensors as a function of device parameters, fluidic environment, charge polarity of biomolecules, etc., and refer to experimental results in literature to support the nonintuitive predictions wherever possible. Our results indicate that the design of Si nanobiosensor is nontrivial and as such, only careful optimization supported by numerical simulation would ensure optimal sensor performance.