LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity
LA allelic heterozygosity of the 5HTTLPR polymorphism is associated with higher cognitive function and lower interpersonal sensitivity
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DOI：
10.1097/ypg.0b013e328010f498
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发表时间：
2007-02-01
影响因子：
0.9
通讯作者：
Ellingrod, Vicki L.
中科院分区：
文献类型：
--
作者：
Fiedorowicz, Jess G.;Moser, David J.;Ellingrod, Vicki L.
编码5-羟色胺转运蛋白的SLC 6A 4基因的多态性区域5 HTTLPR现在被概念化为具有三种主要等位基因变体：LA、LG和S。在这些等位基因中，只有LA等位基因在启动子生产力方面是高功能的（Hu et al.，2005年）。先前对多巴胺能多态性的研究已经证明了与认知和焦虑人格特质的关联（Lesch et al.，1996; Payton等人，2005年）。我们探讨了这些等位基因变异与认知、焦虑和人际关系敏感性指标之间的关系。68名年龄在55-90岁的明确诊断为动脉粥样硬化性血管疾病的成年人提供了爱荷华州大学机构审查委员会批准的知情同意书。通过神经心理状态评估可重复成套测验（RBANS）评估认知功能。焦虑和人际关系敏感的措施，从症状自评量表-90-修订版。使用先前验证的方法对参与者进行5 HTTLPR多态性的基因分型（Heils等人，1996年）。凝胶抽提后直接测序法测定5 HTTLPR L等位基因的A和G多态性。根据LA等位基因总数和LA等位基因杂合性将患者分组。协方差分析探讨了利益的关系，控制年龄，性别和教育。
The polymorphic region 5HTTLPR of the SLC6A4 gene, encoding the serotonin transporter, is now conceptualized as having three primary allelic variants: LA, LG, and S. Of these alleles, only the LA allele is high functioning with regard to promoter productivity (Hu et al., 2005). Previous research of serotonergic polymorphisms has demonstrated associations with cognition and anxious personality traits (Lesch et al., 1996; Payton et al., 2005). We explored associations between these allelic variants and measures of cognition, anxiety, and interpersonal sensitivity.Sixty-eight adults aged 55–90 years with an unequivocal diagnosis of atherosclerotic vascular disease provided informed consent approved by the University of Iowa Institutional Review Board. Cognitive function was assessed via the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Anxiety and interpersonal sensitivity measures were obtained from the Symptom Checklist-90-Revised. Participants were genotyped for the 5HTTLPR polymorphism using previously validated methods (Heils et al., 1996). The A and G polymorphisms of the 5HTTLPR L allele were determined by direct sequencing after gel extraction. Patients were divided into groups on the basis of the total number of LA alleles and heterozygosity at the LA allele. Analysis of covariance explored relationships of interest, controlling for age, sex, and education.