Knowledge, Attitudes, and Experiences of HIV Pre-Exposure Prophylaxis (PrEP) Trial Participants in Botswana.
Knowledge, Attitudes, and Experiences of HIV Pre-Exposure Prophylaxis (PrEP) Trial Participants in Botswana.
复制标题
DOI：
10.4236/wja.2015.51002
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Kebaabetswe PM
中科院分区：
文献类型：
--
作者：
Toledo L;McLellan-Lemal E;Henderson FL;Kebaabetswe PM
最近的临床试验表明，每日剂量的口服TDF/FTC暴露前预防（PrEP）可有效降低人类免疫缺陷（HIV）风险。了解试验参与者对保留和PrEP依从性的看法对于告知未来的PrEP试验以及PrEP计划的扩大和实施至关重要。我们分析了2010年4月对TDF 2研究参与者进行的53次深入访谈，TDF 2研究是一项3期、随机、双盲、安慰剂对照临床试验，在弗朗西斯敦和博茨瓦纳哈博罗内对异性恋男性和女性进行每日口服TDF/FTC。我们检查了参与者对试验的知识、态度和经验，确定了入组和保留的促进因素和障碍，并按研究中心、性别和研究药物依从性比较了参与者的反应。我们的研究结果指出了在PrEP试验和计划中考虑参与者保留和坚持的几个因素，包括进行入学前教育和神话减少咨询，提供参与者义务和副作用症状的准确估计，确保参与者了解不坚持的影响，衡量个人承诺和对研究结果的兴趣，并为参与者建立强大的外部社会支持网络。
Recent clinical trials have shown that a daily dose of oral TDF/FTC pre-exposure prophylaxis (PrEP) is effective in reducing human immunodeficiency (HIV) risk. Understanding trial participants’ perspectives about retention and PrEP adherence is critical to inform future PrEP trials and the scale-up and implementation of PrEP programs. We analyzed 53 in-depth interviews conducted in April 2010 with participants in the TDF2 study, a Phase 3, randomized, double-blind, placebo-controlled clinical trial of daily oral TDF/FTC with heterosexual men and women in Francistown and Gaborone, Botswana. We examined participants’ knowledge, attitudes, and experiences of the trial, identified facilitators and barriers to enrollment and retention, and compared participant responses by study site, sex, and study drug adherence. Our findings point to several factors to consider for participant retention and adherence in PrEP trials and programs, including conducting pre-enrollment education and myth reduction counseling, providing accurate estimates of participant obligations and side effect symptoms, ensuring participant understanding of the effects of non-adherence, gauging personal commitment and interest in study outcomes, and developing a strong external social support network for participants.