CHANGES IN SERUM LIPOPROTEIN PATTERN INDUCED BY ACUTE INFECTIONS
CHANGES IN SERUM LIPOPROTEIN PATTERN INDUCED BY ACUTE INFECTIONS
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DOI：
10.1016/0026-0495(88)90120-5
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发表时间：
1988-09-01
影响因子：
9.8
通讯作者：
TASKINEN, MR
中科院分区：
文献类型：
--
作者：
SAMMALKORPI, K;VALTONEN, V;TASKINEN, MR
为了研究急性感染对血脂和脂蛋白的影响，我们测定了72例感染患者（病毒感染33例，细菌感染39例）急性期、恢复期和完全康复后不同脂蛋白、载脂蛋白A-I、A-II和B的浓度和组成，以及血浆肝素后脂肪酶、脂蛋白脂肪酶（LPL）和肝脂肪酶（HL）的活性。低密度脂蛋白（LDL）质量浓度（P < 0.001）和高密度脂蛋白（HDL）2质量浓度（P < 0.001）在急性感染期间由于胆固醇、磷脂和蛋白质含量的降低而降低。LDL胆固醇在感染急性期降低幅度最大（变化-15%，P < 0.001）， HDL2胆固醇在恢复期降低幅度最大（变化-35%，P < 0.001）。在急性感染期间，LDL变得甘油三酯富集（11.8 v 8.6%, P < 0.0001），而胆固醇缺乏（36.6 v 39.3%, P < 0.0001）。恢复期HDL胆固醇/LDL胆固醇比值明显降低（0.42 +-）。0.15 v 0.53 .+。0.19, p < 0.0001)。急性感染时，载脂蛋白A-I和载脂蛋白A-II浓度下降（分别为-22%，P < 0.001和-16%，P < 0.001）。由于VLDL甘油三酯、胆固醇和磷脂的升高，恢复期的极低密度脂蛋白（VLDL）比恢复后高18%。LPL活性在感染急性期和恢复期均降低，而HL仅在感染急性期降低。观察到的脂蛋白和脂肪酶活性的变化与感染的严重程度有关，但与感染因子无关。总之，血清脂蛋白的浓度和组成在急性感染期间表现出显著的变化，这至少可以部分解释为LPL和HL活性的降低。
To study the effects of acute infections on serum lipids and lipoproteins we measured the concentration and composition of different lipoproteins, apoproteins A-I, A-II, and B, and the activities of plasma postheparin lipolytic enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL) during acute and convalescence phase and after complete recovery in 72 infectious patients (33 with viral infection and 39 with bacterial infection). The mass concentrations of both low density lipoprotein (LDL) (P < .001) and high density lipoprotein (HDL)2 (P < .002)were reduced during acute infections due to the lowering of their cholesterol, phospholipid, and protein contents. The reduction of LDL cholesterol was maximal at the acute stage of infection (change -15%, P < .001) while the reduction of HDL2 cholesterol was maximal during the convalescence (change -35%, P < .001). During acute infections LDL became triglyceride-enriched (11.8 v 8.6%, P < .0001) but cholesterol-poor (36.6 v 39.3%, P < .0001). The ratio of HDL cholesterol/LDL cholesterol was significantly reduced during the convalescence (0.42 .+-. 0.15 v 0.53 .+-. 0.19, P < .0001). The concentrations of apo A-I and apo A-II were decreased during acute infections (changes -22%, P < .001, and -16%, P < .001, respectively). The very low density lipoprotein (VLDL) was 18% higher during the convalescence period than after the recovery due to the elevations of VLDL triglycerides, cholesterol, and phospholipids. The activity of LPL was reduced both in the acute and convalescence phase, whereas that of HL was reduced only in the acute phase of infections. The observed changes of the lipoproteins and lipase activities were related to the severity of infection but were independent of the infective agents. In conclusion, the concentration and composition of serum lipoproteins exhibit striking changes during acute infections which can be explained at least partly by the concomitant reductions of LPL and HL activities.