PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells
PLCE1 Suppresses p53 Expression in Esophageal Cancer Cells
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DOI：
10.3109/07357907.2014.905588
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发表时间：
2014-07-01
影响因子：
2.4
通讯作者：
Zhang, Junhang
中科院分区：
文献类型：
--
作者：
Li, Yun;An, Jun;Zhang, Junhang
凋亡机制功能障碍在癌细胞生长和逃避癌症治疗中起关键作用;其潜在机制有待进一步阐明。本研究旨在探讨磷脂酶C β 1（PLCE 1）在食管癌（Eca）细胞凋亡调控中的作用。结果显示，Eca细胞系、OE 33和CP-C细胞表达高水平的PLCE 1。PLCE 1基因的敲除可通过调控p53启动子甲基化使CP-C细胞p53表达增加9.26倍，凋亡率增加13.8倍。
The apoptotic mechanism dysfunction plays a critical role in cancer cell growth and escaping from cancer therapies; the underlying mechanisms are to be further elucidated. This study aims to investigate the role of phospholipase C epsilon 1 (PLCE1) in modulating the apoptosis mechanism in esophageal cancer (Eca) cells. The results showed that Eca cell lines, OE33 and CP-C cells expressed high levels of PLCE1. Knockdown of PLCE1 markedly increased 9.26 folds of the expression of p53 and 13.8 folds of the frequency of apoptotic CP-C cells via modulating the p53 promoter methylation.