Uncertainty in contextual and kinematic cues jointly modulate motor resonance in primary motor cortex
Uncertainty in contextual and kinematic cues jointly modulate motor resonance in primary motor cortex
复制标题
情境和运动学线索的不确定性共同调节初级运动皮层的运动共振
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
N. Wenderoth
中科院分区：
文献类型：
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作者：
A. Cretu;K. Ruddy;Maria Germann;N. Wenderoth
伴随他人动作的情境信息调节“运动共振”，即运动观察引起的运动区域内的神经活动。一种可能性是，我们根据这些信息的相对不确定性，以贝叶斯方式对它们进行加权和联合收割机组合。因此，当其他人的动作是模糊的时，上下文信息变得特别有用。然而，目前还不清楚这种不确定性是否会在运动观察过程中调节初级运动皮层（M1）的神经活动。在这里，我们应用单脉冲经颅磁刺激（TMS），而受试者观看不同的抓握动作。我们将运动共振操作化为在指数（FDI）与小指外展肌（ADM）中测量的皮质运动兴奋性的抓握特异性调制。我们实验调制的可用性的运动学信息（实验。1)或上下文线索的可靠性（Exp. 2）。我们的研究结果表明，即使在缺乏运动学的情况下，可靠的背景信息也足以触发M1中显著的肌肉特异性皮质运动兴奋性变化（p<.0001），当运动学和背景信息都可用时，这种变化最强（p<.005）。这些研究结果表明，自下而上的机制，激活电机表征作为所观察到的运动学的函数，和自上而下的机制，激活电机表征与任意线索收敛在M1在统计上最佳的方式。
Contextual information accompanying others’ actions modulates “motor resonance”, i.e. neural activity within motor areas that is elicited by movement observation. One possibility is that we weight and combine such information in a Bayesian manner according to their relative uncertainty. Therefore, contextual information becomes particularly useful when others’ actions are ambiguous. It is unclear, however, whether this uncertainty modulates the neural activity in primary motor cortex (M1) during movement observation. Here we applied single-pulse transcranial magnetic stimulation (TMS) while subjects watched different grasping actions. We operationalized motor resonance as grip specific modulation of corticomotor excitability measured in the index (FDI) versus the little finger abductor (ADM). We experimentally modulated either the availability of kinematic information (Exp. 1) or the reliability of contextual cues (Exp. 2). Our results indicate that even in the absence of movement kinematics, reliable contextual information is enough to trigger significant muscle-specific corticomotor excitability changes in M1 (p<.0001) which are strongest when both kinematics and contextual information are available (p<.005). These findings suggest that bottom-up mechanisms that activate motor representations as a function of the observed kinematics, and top-down mechanisms which activate motor representations associated with arbitrary cues converge in M1 in a statistically optimal manner.
影响因子：
4.8
作者：
Cross, Emily S.;Stadler, Waltraud;Prinz, Wolfgang
通讯作者：
Prinz, Wolfgang
相比初级运动皮层的阳极 tDCS 对于通过观察学习运动序列没有任何优势
DOI：
10.3929/ethz-b-000628007
发表时间：
2018
期刊：
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影响因子：
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作者：
Apšvalka, Dace
通讯作者：
Apšvalka, Dace