Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus.
Longitudinal expression of type I interferon responsive genes in systemic lupus erythematosus.
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DOI：
10.1177/0961203309105529
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发表时间：
2009-10
期刊：
影响因子：
2.6
通讯作者：
Baechler E
中科院分区：
文献类型：
--
作者：
Petri M;Singh S;Tesfasyone H;Dedrick R;Fry K;Lal P;Williams G;Bauer J;Gregersen P;Behrens T;Baechler E
对系统性红斑狼疮(SLE)患者的横断面研究表明，I型干扰素途径的激活与疾病活动性之间存在关联。这项研究利用微阵列技术检测了外周血液中干扰素调控基因表达的纵向变化。对来自自身免疫生物标记物协作网络SLE档案的66名患者的横断面进行了评估。我们还检查了在疾病低活动期(基线)和随后的耀斑事件期间收集的15名患者亚组的配对样本，以及29名保持低疾病活动的患者的基线评分。计算3个干扰素调控基因的干扰素应答(IFNr)评分。总体而言，IFNr评分越高，疾病活动性越强。然而，IFNr评分在配对基线样本和耀斑样本之间没有显著差异。对11名患者的扩展纵向分析表明，IFNr评分随着时间的推移几乎没有变化，即使在动态疾病活动期间也是如此。在疾病活动性较低的患者中，IFNr评分在经历了随后的病情暴发和保持较低疾病活动性的患者之间没有差异。综上所述，尽管IFNr评分越高，疾病活动性越强，但个体患者的IFNr评分与疾病严重程度或红斑风险的变化无关。
Cross-sectional studies of patients with systemic lupus erythematosus (SLE) have demonstrated an association between activation of type I interferon (IFN) pathway and disease activity. This study examined longitudinal changes in IFN-regulated gene expression in peripheral blood using microarrays. A cross-section of 66 patients from the Autoimmune Biomarkers Collaborative Network SLE archive was evaluated. We also examined paired samples from a 15 patient subset collected during a period of low disease activity (Baseline) and at a subsequent flare event, and baseline scores of 29 patients who maintained low disease activity. IFN response (IFNr) scores were calculated from three IFN-regulated genes. Overall, higher IFNr scores were associated with increased disease activity. However, IFNr scores were not significantly different between the paired Baseline and Flare samples. An extended longitudinal analysis in 11 patients indicated little change in IFNr scores over time, even during dynamic disease activity. In patients with low disease activity, IFNr scores were not different between patients who experienced a subsequent flare and those who maintained low disease activity. In summary, although higher IFNr scores were associated with greater disease activity, IFNr scores of individual patients did not correlate with changes in disease severity or flare risk.