Innate versus learned odour processing in the mouse olfactory bulb
Innate versus learned odour processing in the mouse olfactory bulb
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DOI：
10.1038/nature06281
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发表时间：
2007-11-22
期刊：
影响因子：
64.8
通讯作者：
Sakano, Hitoshi
中科院分区：
文献类型：
--
作者：
Kobayakawa, Ko;Kobayakawa, Reiko;Sakano, Hitoshi
哺乳动物的嗅觉系统介导各种反应，包括对腐败食物的厌恶行为和对捕食者气味的恐惧反应。在嗅球中，每个小球代表一种单一的气味受体。因为一个单一的气味可以与几种不同的受体相互作用，在嗅上皮中接收到的气味信息被转换为在嗅球的不同区域激活的多个肾小球的地形图。为了研究气味图是如何在大脑中解释的，我们产生了突变小鼠，其中嗅觉上皮特定区域的嗅觉感觉神经元被白喉毒素基因的靶向表达所消融。在这里，我们表明，在背区耗尽小鼠，背域的嗅球是缺乏肾小球结构，虽然二级神经元存在于空置的地区。突变小鼠缺乏对厌恶气味的先天反应，即使它们能够检测到它们，并且可以通过剩余的肾小球进行条件反射。这些结果表明，在小鼠中，厌恶的信息是通过不同的肾小球接收的，这些肾小球专门用于先天反应和后天反应。
The mammalian olfactory system mediates various responses, including aversive behaviours to spoiled foods and fear responses to predator odours. In the olfactory bulb, each glomerulus represents a single species of odorant receptor. Because a single odorant can interact with several different receptor species, the odour information received in the olfactory epithelium is converted to a topographical map of multiple glomeruli activated in distinct areas in the olfactory bulb. To study how the odour map is interpreted in the brain, we generated mutant mice in which olfactory sensory neurons in a specific area of the olfactory epithelium are ablated by targeted expression of the diphtheria toxin gene. Here we show that, in dorsal-zone-depleted mice, the dorsal domain of the olfactory bulb was devoid of glomerular structures, although second-order neurons were present in the vacant areas. The mutant mice lacked innate responses to aversive odorants, even though they were capable of detecting them and could be conditioned for aversion with the remaining glomeruli. These results indicate that, in mice, aversive information is received in the olfactory bulb by separate sets of glomeruli, those dedicated for innate and those for learned responses.