Rheb G-Proteins and the Activation of mTORC1.
Rheb G-Proteins and the Activation of mTORC1.
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DOI：
10.1016/s1874-6047(10)27003-8
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Tamanoi, Fuyuhiko
中科院分区：
文献类型：
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作者：
Parmar, Nitika;Tamanoi, Fuyuhiko
Rheb属于G蛋白Ras超家族中的一个独特家族。虽然最初在大鼠脑中发现，但这种G蛋白从酵母到人类高度保守。虽然在低等真核生物中仅存在一种Rheb，但在哺乳动物细胞中存在两种Rheb蛋白。许多研究证实，Rheb的功能之一是激活mTOR，导致生长。特别是，Rheb在体外激活mTORC1的能力表明Rheb与mTORC1复合物直接相互作用。还提出了Rheb独立于mTOR的其他功能。
Rheb belongs to a unique family within the Ras superfamily of G-proteins. Although initially identified in rat brain, this G-protein is highly conserved from yeast to human. While only one Rheb is present in lower eukaryotes, two Rheb proteins exist in mammalian cells. A number of studies establish that one of the functions of Rheb is to activate mTOR leading to growth. In particular, the ability of Rheb to activate mTORC1 in vitro points to direct interaction of Rheb with the mTORC1 complex. Additional functions of Rheb that are independent of mTOR have also been suggested.