Hypopharyngeal squamous cell carcinoma bordering ectopic gastric mucosa "inlet patch" of the cervical esophagus
Hypopharyngeal squamous cell carcinoma bordering ectopic gastric mucosa "inlet patch" of the cervical esophagus
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DOI：
10.1016/j.anl.2006.05.014
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发表时间：
2007-03-01
影响因子：
1.7
通讯作者：
Inokuchi, Akira
中科院分区：
文献类型：
--
作者：
Satoh, Shintaro;Nakashima, Toshiyuki;Inokuchi, Akira
目的：颈段食管胃粘膜异位，又称入口斑（inlet patch，IP），是一种常见的食管发育异常。我们报告一例下咽鳞状细胞癌毗邻颈段食管IP。方法：一位44岁女性在诊断下咽癌的情况下接受了部分咽切除术、全喉切除术、颈段食管切除术和双侧颈淋巴结清扫术。下咽部的切除标本显示在溃疡性肿瘤病变（3.5 cm x 0.5 cm）中存在分化良好的鳞状细胞癌。与肿瘤肛门面接壤的棕色斑块（2 cm x 1.5 cm）由胃底型上皮的异位胃粘膜组成。免疫组化结果显示，该病变的表面粘膜细胞呈强阳性的人胃粘蛋白（HGM）和胃底细胞呈阳性gastrin.Conclusion：下咽鳞状细胞癌可能发展与慢性刺激，由于胃酸从IP。据我们所知，这是第一例与IP相关的鳞状细胞癌报告。(C)2006爱思唯尔爱尔兰有限公司保留所有权利。
Objective: Ectopic gastric mucosa of the cervical esophagus, referred to as inlet patch (IP), is considered to be a common development abnormality of the esophagus. We report here a case of hypopharyngeal squamous cell carcinoma bordering on IP of the cervical esophagus.Methods: A 44-year-old female underwent partial pharyngectomy, total laryngectomy, cervical esophagectomy, and bilateral neck dissection under the diagnosis of hypopharyngeal carcinoma.Results: Resected specimens of the hypopharynx revealed a well-differentiated squamous cell carcinoma in the ulcerative tumorous lesion (3.5 cm x 0.5 cm). A brown patch (2 cm x 1.5 cm) bordering the anal aspect of the tumor comprised ectopic gastric mucosa of fundic type epithelium. Immunohistochemistry revealed the surface mucosal cells of this lesion were strongly positive for human gastric mucin (HGM) and the fundic cells were positive for gastrin.Conclusion: The hypopharyngeal squamous cell carcinoma likely developed in association with chronic irritation due to gastric acid from the IP. To our knowledge, this is the first reported case of squamous cell carcinoma related to IP. (C) 2006 Elsevier Ireland Ltd. All rights reserved.