Alopecia areata as a model for T cell-dependent autoimmune diseases
Alopecia areata as a model for T cell-dependent autoimmune diseases
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DOI：
10.1111/j.1600-0625.2011.01427.x
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发表时间：
2012-06-01
影响因子：
3.6
通讯作者：
Paus, Ralf
中科院分区：
文献类型：
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作者：
Bertolini, Marta;Gilhar, Amos;Paus, Ralf
2011年9月，在德国吕贝克举行的一次国际研讨会系统地探讨了人类最常见但最不受重视的自身免疫性疾病之一斑秃（AA）作为T细胞特异性自身免疫性疾病的模型。会议由德国研究基金会、全国斑秃基金会、吕贝克大学、不列颠哥伦比亚省、曼彻斯特大学和以色列技术研究所赞助。为了展示和辩论新的AA数据和见解，研讨会主席（Ralf Paus，Amos Gilhar）召集了专业的AA研究人员，基础免疫学家和遗传学家。他们共同追求的整体研讨会的目的是促进未来的跨学科合作，对相关的AA研究，批判性地讨论可用的AA研究模型，并确定在该领域的紧迫研究重点。此外，研讨会将AA作为一个遗憾的未被充分利用，但非常有指导意义和可访问的一般模型，其中与其他经典T细胞依赖性自身免疫性疾病[例如多发性硬化症（MS）]相关的中心问题可以作为范例进行研究：AA和这些器官特异性自身免疫性疾病的关键特征，如相对免疫特权（IP）的崩溃。Andrew Messenger（谢菲尔德大学，谢菲尔德，英国）从临床角度概述了AA发病机制及其许多谜团。据报道，AA导致脱发，可能涉及头皮和/或身体的任何其他毛发承载部分（1）。终身风险约为1.7%（2），具有很强的遗传成分（3）。AA通常与其他自身免疫性疾病（如甲状腺疾病、白癜风和糖尿病）和慢性炎症性疾病（如特应性和银屑病）相关（4，5）。他提醒参与者，醋酸曲安西龙注射和强制性合成过敏原的接触免疫疗法仍然是唯一可以被认为是合理循证医学的AA治疗形式（5），即使它们在更多AA患者中失败了。
In September 2011, an international workshop in Lübeck, Germany, systematically explored one of the most frequent, but least-appreciated autoimmune diseases of man, alopecia areata (AA), as a model for T cell-specific autoimmune diseases. The meeting was sponsored by the German Research Foundation (DFG), the National Alopecia Areata Foundation (NAAF), the Universities of Lübeck, British Columbia, Manchester and the Technion–Israel Institute. To present and publically debate new AA data and insights, the workshop chairmen (Ralf Paus, Amos Gilhar) brought together professional AA researchers, basic immunologists and geneticists. They jointly pursued the overall workshop aims to foster future interdisciplinary collaborations on translationally relevant AA research, to critically discuss available AA research models and to define urgent research priorities in the field. Moreover, the workshop promoted AA as a–regrettably under-utilized, but very instructive and accessible–general model in which central problems relevant to other classical T cell-dependent autoimmune diseases [eg multiple sclerosis (MS)] can be studied exemplarily: AA and these organ-specific autoimmune diseases share key features such as the collapse of relative immune privilege (IP).In his opening lecture, Andrew Messenger (University of Sheffield, Sheffield, UK) presented an overview of AA pathogenesis and its many enigmas from the clinical perspective. As reported, AA results in hair loss which can involve the scalp and⁄ or any other hair-bearing part of the body (1). The lifetime risk is about 1.7%(2) with strong heritable components (3). AA often manifests in association with other autoimmune (eg thyroid disease, vitiligo and diabetes mellitus) and chronic inflammatory diseases (eg atopy and psoriasis)(4, 5). He reminded the participants that triamcinolone acetate injections and contact immunotherapy with obligatory synthetic allergens remain the only forms of AA therapy that can be considered reasonably evidence-based medicine (5), even though they do fail in more AA patients than one would hope for.