Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption.
Effect of acamprosate and naltrexone, alone or in combination, on ethanol consumption.
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DOI：
10.1016/s0741-8329(00)00137-3
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发表时间：
2001-02
期刊：
影响因子：
2.3
通讯作者：
M. F. Stromberg;S. Mackler;J. Volpicelli;Charles P. O'Brien
中科院分区：
文献类型：
--
作者：
M. F. Stromberg;S. Mackler;J. Volpicelli;Charles P. O'Brien
阿坎酸和纳洛酮都已证明在减少恢复酗酒者的酒精使用复发方面的临床效用。本实验研究了阿坎酸和纳洛酮单独或组合对使用远交Wistar大鼠的有限访问模型中的基础乙醇消耗的影响。如前所述，0.1 mg/kg的纳洛酮显著降低了乙醇消耗。单独给药时，50 mg/kg阿坎酸未显著降低乙醇消耗，与纳洛酮联合给药时，未提供累加或协同效应的证据。阿坎酸，200毫克/公斤，产生了适度减少乙醇消耗时，单独给药，但没有证据表明，累加或协同作用时，与纳洛酮组合。从这些发现，这表明，这些药物的组合方法可能不会比单药治疗更有效。
Both acamprosate and naltrexone have demonstrated clinical utility in reducing relapse to alcohol use in recovering alcoholics. The present experiments examined the effects of acamprosate and naltrexone, either alone or in combination, on basal ethanol consumption in a limited-access model with the use of outbred Wistar rats. Naltrexone, 0.1 mg/kg, significantly reduced ethanol consumption as previously reported. Acamprosate, 50 mg/kg, did not significantly reduce ethanol consumption when administered alone and provided no evidence of additive or synergistic effects when combined with naltrexone. Acamprosate, 200 mg/kg, produced a modest reduction in ethanol consumption when administered alone but no evidence of additive or synergistic effects when combined with naltrexone. From these findings, it is suggested that a combination approach of these drugs may not be any more effective than monotherapy.