Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)
Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)
复制标题
DOI：
10.1007/s10552-006-0069-8
复制
发表时间：
2007-03-01
影响因子：
2.3
通讯作者：
Tamakoshi, Akiko
中科院分区：
文献类型：
--
作者：
Kondo, Takaaki;Hori, Yoko;Tamakoshi, Akiko
为了确定成年后体重指数(BMI)及其变化与日本肺癌死亡率的关系，在1988年至1990年发起的日本癌症风险评估合作队列研究(JACC Study)中，我们对29,350名男性进行了长达11年的跟踪。以年龄、吸烟状况和肺癌家族史为协变量，采用互补对数-对数模型。使用的人体测量学测量是基线时的BMI，20岁左右的BMI，以及两种测量之间定义的成年BMI损失。通过将广义估计方程的方法应用到调整个体内相关性的模型中，评估了这三种测量方法对肺癌死亡率的独立影响。从未吸烟者显示，基线和20岁左右的高BMI均显著预测肺癌死亡率(P<；0.05)。成年后体重指数下降显著(P<；0.05)增加了当前吸烟者中肺癌死亡的风险，这意味着吸烟者对肺癌风险的易感性增加。肺癌死亡风险的增加与成年期间吸烟导致的体重减轻有关。
To determine the relationship of body mass index (BMI) and BMI changes during adulthood to lung cancer mortality in a large-sized Japanese cohort.We followed 29,350 men for a maximum of 11 years in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated from 1988 to 1990. Complementary log-log modeling was employed with age, smoking status, and family history of lung cancer as covariates. Anthropometric measurements used were BMI at baseline, BMI around age 20, and adulthood BMI loss defined between the two measurements. Independent effects of these three measurements on lung cancer mortality were evaluated by applying the method of generalized estimation equations to the model for adjustment of intra-individual correlation.Never smokers showed that high BMI both at baseline and around age 20 significantly predict lung cancer mortality (P < 0.05). Adulthood BMI loss significantly (P < 0.05) elevated the risk for lung cancer mortality among current smokers, implying their enhanced vulnerability to lung cancer risk among smokers.The risk for lung cancer mortality is elevated by a mechanism related to smoking-induced weight loss during adulthood.