Immunology of insulin-dependent diabetes mellitus.
Immunology of insulin-dependent diabetes mellitus.
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DOI：
10.1146/annurev.iy.03.040185.001445
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发表时间：
1985
影响因子：
29.7
通讯作者：
A. Rossini;J. Mordes;A. Like
中科院分区：
文献类型：
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作者：
A. Rossini;J. Mordes;A. Like
我们试图说明在人类胰岛素依赖型糖尿病和这种疾病的动物模型的研究的主要趋势。我们强调了动物模型的实用性和重要性。它们对了解人类疾病的贡献是巨大的，但其使用中固有的局限性也应该是显而易见的。从啮齿动物到人类的推断总是不可靠的。尽管如此，动物仍然为揭示糖尿病的发病机制提供了很大的希望。在BB大鼠中获得的优异结果已经导致环孢菌素在人体试验中的使用。很明显，我们已经从糖尿病动物身上学到了很多东西，它们还有很多东西要教我们。希望对人类胰岛素依赖型糖尿病发病机制的进一步了解将有助于安全有效的预防性和治疗性治疗。
We have attempted to illustrate the major trends in research in human IDDM and in the animal models of this disease. We have stressed the utility and importance of the animal models. Their contribution to understanding the human disease is great but the limitations inherent in their use should also be evident. Extrapolation from rodent to human is always treacherous. Nonetheless, the animals still offer great promise in unraveling the pathogenesis of diabetes. The excellent results obtained in BB rats have already led to the use of cyclosporin in human trials. It is clear that we have learned a great deal from diabetic animals and that they have a good deal yet to teach us. Hopefully, an enhanced understanding of the pathogenesis of human insulin-dependent diabetes will follow and lead to preventive and curative therapies that are both safe and effective.