New C13 lipids from the marine-derived fungus Trichoderma harzianum
New C13 lipids from the marine-derived fungus Trichoderma harzianum
复制标题
来自海洋真菌哈茨木霉的新 C13 脂质
DOI：
10.1080/10286020.2015.1042371
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发表时间：
2015-05-04
影响因子：
1.7
通讯作者：
Lin, Wen-Han
中科院分区：
文献类型：
--
作者：
Li, Bo;Huang, Qi-Xi;Lin, Wen-Han
对海绵相关真菌哈茨木霉（Trichoderma harzinum）HMS-15-3的发酵液进行化学检查，分离出四对新的C-13脂质对映体，即harzipentadiols A-H（1a-4 b）。它们的结构被阐明的基础上，广泛的光谱（IR，MS，1D，和2D NMR）数据分析，包括修改后的Mosher的方法分配其绝对构型。在HepG 2细胞中评价新化合物的抗高血压作用。
Chemical examination of the fermentation broth of a sponge-associated fungus Trichoderma harzinum HMS-15-3 led to the isolation of four pairs of new C-13 lipid enantiomers namely harzianumols A-H (1a-4b). Their structures were elucidated on the basis of extensive spectroscopic (IR, MS, 1D, and 2D NMR) data analysis, including the modified Mosher's method for the assignment of their absolute configurations. The new compounds were evaluated for antihyperlipidemic effects in HepG2 cells.