Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Hippocampal Integrity and Volume at Midlife
Visit-to-Visit Fasting Glucose Variability in Young Adulthood and Hippocampal Integrity and Volume at Midlife
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青年期访视空腹血糖变异性和中年海马完整性和体积
DOI：
10.2337/dc19-0834
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发表时间：
2019
期刊：
影响因子：
16.2
通讯作者：
Xinxue Liao
中科院分区：
文献类型：
--
作者：
Zhenyu Xiong;Jiaying Li;Xiangbin Zhong;Shaozhao Zhang;Xiuting Sun;Huimin Zhou;Yunzhi Chen;Xiaodong Zhuang;Xinxue Liao
目的为了确定青年时期来访的空腹血糖(VVFG)变异性是否与中年海马的完整性和体积有关，采用研究设计和方法调整多元线性回归模型对543名CARDIA研究参与者的VVFG变异性与脑MRI变量之间的关系进行了估计。VVFG变异性由FG的标准差(SDFG)、平均FG的变异系数(CVFG)和25年的平均真实变异性(ARVFG)来定义。结果多变量调整后，高FG变异性(1-SD增加)与低的海马区FA相关(SDFG−0.015[95%CI−0.026，−0.004]；CVFG−0.009[95%CI−0.018，−0.001]；ARVFG−0.011[95%CI−0.019，−0.002])和较低的海马体积(SDFG−0.012[95%CI−0.023，−0.001])。结论青年VVFG变异性高与中年海马完整性和体积低相关，提示其在预测海马结构损伤风险方面的价值。
OBJECTIVETo determine whether visit-to-visit fasting glucose (VVFG) variability in young adulthood is associated with midlife hippocampal integrity and volume.RESEARCH DESIGN AND METHODSMultivariable-adjusted linear regression models were used to estimate the association between VVFG variability and brain MRI variables in 543 CARDIA study participants. VVFG variability was defined by the SD of FG (SDFG), the coefficient of variation of the mean FG (CVFG), and the average real variability (ARVFG) over 25 years of follow-up. Hippocampal integrity fractional anisotropy (FA) and tissue volume standardized to intracranial volume were measured by 3T MRI at year 25.RESULTSAfter multivariable adjustment, higher FG variability (1-SD increase) was associated with lower hippocampal FA (SDFG−0.015 [95% CI −0.026, −0.004]; CVFG−0.009 [95% CI −0.018, −0.001]; ARVFG−0.011 [95% CI −0.019, −0.002]) and lower hippocampal volume (SDFG−0.012 [95% CI −0.023, −0.001]).CONCLUSIONSHigher VVFG variability in young adulthood is associated with lower midlife hippocampal integrity and volume, suggesting its value in predicting risk for hippocampal structural damage.