Influence of site of regional ischemia on nonischemic thickening in anesthetized dogs.
Influence of site of regional ischemia on nonischemic thickening in anesthetized dogs.
复制标题
局部缺血部位对麻醉犬非缺血性增厚的影响。
DOI：
10.1152/ajpheart.1989.256.5.h1417
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Weiss,JL
中科院分区：
文献类型：
--
作者：
Marino,PN;Kass,DA;Becker,LC;Lima,JA;Weiss,JL
通过比较 8 只开胸狗的 2-3 分钟回旋支 (Circ) 与左前降支 (LAD) 冠状动脉闭塞期间的区域增厚，检查不同急性局部缺血部位对非缺血性心肌功能的影响。获得横断面中壁二维超声心动图，并在圆周周围 16 个等距点测量收缩期增厚。通过放射性标记的微球评估灌注不足的分布和程度。回声切片被细分为低灌注区域（Hypo）、四个相邻的非缺血区域（ADJ1-4）和剩余的远程段（Remote）。两组闭塞的低灌注程度（%LV 质量）相似（LAD，29.4 +/- 2.8%；Circ，26.0 +/- 4.4%；P = NS），非缺血区域的心内膜和心外膜血流也相似。然而，即使具有相似大小的 Hypo 区域，Circ 期间非缺血心肌的增厚也明显大于 LAD 闭塞期间（P 小于 0.001）。这些结果与最近报道的 LAD 与 Circ 缺血期间整体功能损伤的差异一致。这些反应可能反映了两个血管区域之间局部壁几何形状、负荷和冠状动脉灌注不足的三维分布的差异。
The effect of varying the site of acute regional ischemia on nonischemic myocardial function was examined by comparing regional thickening during 2-3 min circumflex (Circ) vs. left anterior descending (LAD) coronary artery occlusions in eight open-chest dogs. Cross-sectional midwall two-dimensional echocardiograms were obtained, and systolic thickening was measured at 16 equal-spaced points around the circumference. The distribution and extent of hypoperfusion was assessed by radiolabeled microspheres. The echo slice was subdivided into a hypoperfused region (Hypo), four adjacent nonischemic regions (ADJ1-4), and the remaining remote segments (Remote). The extent of hypoperfusion (%LV mass) was similar with both sets of occlusions (LAD, 29.4 +/- 2.8%; Circ, 26.0 +/- 4.4%; P = NS), as was endo- and epicardial flow in the nonischemic regions. Yet, even with like-sized Hypo regions, thickening of nonischemic myocardium was significantly greater during Circ than during LAD occlusions (P less than 0.001). These results are consistent with recently reported disparities of global functional impairment during LAD vs. Circ ischemia. The responses likely reflect differences in regional wall geometry, loading, and the three-dimensional distribution of coronary hypoperfusion between the two vascular territories.