REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS
REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS
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DOI：
10.1126/science.7520605
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发表时间：
1994-08-26
期刊：
影响因子：
56.9
通讯作者：
WEINER, HL
中科院分区：
文献类型：
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作者：
CHEN, YH;KUCHROO, VK;WEINER, HL
实验性自身免疫性脑脊髓炎（EAE）是一种细胞介导的自身免疫性疾病，可作为多发性硬化症的动物模型。口服髓鞘碱性蛋白（MBP）通过诱导外周耐受抑制EAE。从口服MBP耐受的SJL小鼠的肠系膜淋巴结中分离T细胞克隆。这些克隆是CD 4（+），并且在T细胞受体使用、主要组织相容性复合物限制和表位识别方面与T辅助细胞1型（T（H）1）致脑炎性CD 4（+）克隆在结构上相同。然而，它们产生转化生长因子-β与不同量的白细胞介素-4和白细胞介素-10，并抑制由MBP或蛋白脂质蛋白诱导的EAE。因此，由口服抗原诱导的粘膜来源的T（H）2样克隆可以在体内积极调节免疫应答，并且可能代表T细胞的不同亚群。
Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease that serves as an animal model for multiple sclerosis. Oral administration of myelin basic protein (MBP) suppresses EAE by inducing peripheral tolerance. T cell clones were isolated from the mesenteric lymph nodes of SJL mice that had been orally tolerized to MBP. These clones were CD4(+) and were structurally identical to T helper cell type 1 (T(H)1) encephalitogenic CD4(+) clones in T cell receptor usage, major histocompatibility complex restriction, and epitope recognition. However, they produced transforming growth factor-beta with various amounts of interleukin-4 and interleukin-10 and suppressed EAE induced with either MBP or proteolipid protein. Thus, mucosally derived T(H)2-like clones induced by oral antigen can actively regulate immune responses in vivo and may represent a different subset of T cells.