FABRICATION OF MULTILUMEN MICROFLUIDIC TUBING FOR EX SITU DIRECT LASER WRITING.
FABRICATION OF MULTILUMEN MICROFLUIDIC TUBING FOR EX SITU DIRECT LASER WRITING.
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用于异地直接激光书写的多腔微流体管的制造。
DOI：
10.1109/mems58180.2024.10439522
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发表时间：
2024
期刊：
影响因子：
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通讯作者：
Sochol,RyanD
中科院分区：
文献类型：
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作者：
Felix,BaileyM;Young,OliviaM;Andreou,JordiT;Sarker,Sunandita;Fuge,MarkD;Krieger,Axel;Weiss,CliffordR;Bailey,ChristopherR;Sochol,RyanD
在众多的增材制造或“三维（3D）打印”技术中，双光子直接激光写入（DLW）特别适合于需要具有微米至亚微米尺度特征分辨率的高几何通用性的应用。最近，“非原位DLW（esDLW）”已经成为直接在可手动操纵的中/宏观尺度流体管顶上打印3D微流体结构的有力方法;然而，在这种尺度下创建定制的esDLW兼容的多腔管的困难阻碍了进展。为了解决这一障碍，我们在这里介绍了一种用于制造esDLW 3D打印的亚毫米多腔管的新方法。初步的制造结果表明，该策略的实用性，解决743 μ m的直径管与三个管腔，每个内径（ID）为80 μm。实验结果不仅揭示了通过三个管腔中的每一个的离散荧光标记流体的独立流动，而且还揭示了在管顶部的示范性3D“MEMS”微结构的有效esDLW打印。这些结果表明，所提出的方法可以提供一种有前途的途径，使几何形状复杂的微流体系统能够3D打印，其中输入和/或输出端口完全密封到流体管道的多个不同管腔，用于从药物输送和医疗诊断到软手术机器人等领域的新兴应用。
Among the numerous additive manufacturing or "three-dimensional (3D) printing" techniques, two-photon Direct Laser Writing (DLW) is distinctively suited for applications that demand high geometric versatility with micron-to-submicron-scale feature resolutions. Recently, "ex situ DLW (esDLW)" has emerged as a powerful approach for printing 3D microfluidic structures directly atop meso/macroscale fluidic tubing that can be manipulated by hand; however, difficulties in creating custom esDLW-compatible multilumen tubing at such scales has hindered progress. To address this impediment, here we introduce a novel methodology for fabricating submillimeter multilumen tubing for esDLW 3D printing. Preliminary fabrication results demonstrate the utility of the presented strategy for resolving 743 μm-in-diameter tubing with three lumens—each with an inner diameter (ID) of 80 μm. Experimental results not only revealed independent flow of discrete fluorescently labelled fluids through each of the three lumens, but also effective esDLW-printing of a demonstrative 3D “MEMS” microstructure atop the tubing. These results suggest that the presented approach could offer a promising pathway to enable geometrically sophisticated microfluidic systems to be 3D printed with input and/or output ports fully sealed to multiple, distinct lumens of fluidic tubing for emerging applications in fields ranging from drug delivery and medical diagnostics to soft surgical robotics.