ANTIPERINUCLEAR FACTOR IN JUVENILE RHEUMATOID-ARTHRITIS
ANTIPERINUCLEAR FACTOR IN JUVENILE RHEUMATOID-ARTHRITIS
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DOI：
10.1136/ard.51.3.350
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发表时间：
1992-03-01
影响因子：
27.4
通讯作者：
OSBORN, TG
中科院分区：
文献类型：
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作者：
NESHER, G;MOORE, TL;OSBORN, TG
少年类风湿性关节炎（JRA）的血清学诊断比较困难，只有7-10%的患者19S IgM类风湿因子阳性。约60-70%的患者对隐藏的19S IgM类风湿因子呈阳性，但该试验需要血清分离，在大多数实验室无法获得。抗核周因子在血清阳性和血清阴性的成人类风湿关节炎患者中均有报道，但在儿童类风湿关节炎患者中尚未得到全面评估。本研究确定了抗核周因子在JRA患者诊断中的敏感性和特异性。对64例JRA患儿、24例系统性红斑狼疮（SLE）患儿和24例对照者进行血清抗核周因子检测。共有10例（83%）血清阳性，多关节发病，6例（37%）血清阴性，多关节发病的JRA患者抗核周因子阳性。与对照组（1/24(4%)）相比，少关节起病和1例（10%）全身性起病（JRA）以及4例（17%）SLE的发生率均未增加。这些数据显示，该组患者的总体诊断敏感性和特异性分别为34%和90%。虽然不像隐藏的类风湿因子检测那样敏感，但抗核周因子检测更容易进行，可能有助于JRA的血清学诊断。
The serological diagnosis of juvenile rheumatoid arthritis (JRA) is difficult, with only 7-10% of patients 19S IgM rheumatoid factor positive. About 60-70% of patients are positive for hidden 19S IgM rheumatoid factor, but this test requires serum separation and is not available in most laboratories. Antiperinuclear factor has been described in both seropositive and seronegative adult patients with rheumatoid arthritis, but has not been thoroughly evaluated in children with JRA. This study determined the diagnostic sensitivity and specificity of antiperinuclear factor in patients with JRA.Serum samples from 64 children with JRA, 24 with systemic lupus erythematosus (SLE), and 24 control subjects were tested for the presence of antiperinuclear factor. A total of 10 (83%) of seropositive, polyarticular onset and six (37%) of seronegative, polyarticular onset patients with JRA were positive for antiperinuclear factor. The occurrence of pauciarticular onset and one (10%) with systemic onset (JRA) as well as in four (17%) with SLE was not increased compared with the control subjects (1/24 (4%)).These data show an overall diagnostic sensitivity and specificity of 34 and 90% respectively in this group of patients. Although less sensitive than the hidden rheumatoid factor assay, the antiperinuclear factor assay is easier to perform and may contribute to the serological diagnosis of JRA.