NHC-catalyzed oxidative gamma-addition of alpha,beta-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones
NHC-catalyzed oxidative gamma-addition of alpha,beta-unsaturated aldehydes to isatins: a high-efficiency synthesis of spirocyclic oxindole-dihydropyranones
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NHC催化α,β-不饱和醛与靛红的氧化γ-加成：螺环羟吲哚-二氢吡喃酮的高效合成
DOI：
10.1039/c3ob42008f
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发表时间：
2014
影响因子：
3.2
通讯作者：
Yao Changsheng
中科院分区：
文献类型：
--
作者：
Liu Rui;Yu Chenxia;Xiao Zhaoxin;Li Tuanjie;Wang Xiangshan;Xie Yuanwei;Yao Changsheng
该手稿公开了通过N-杂环卡宾（NHC）催化的带有γ-H的α，β-不饱和醛与靛红衍生物的氧化γ-官能化有效构建螺环羟吲哚-二氢吡喃酮骨架。原料易得、后处理简单、反应条件温和、产物具有潜在的应用价值，这些都使该方法具有吸引力。
This manuscript discloses an efficient construction of the spirocyclic oxindole-dihydropyranone scaffold via the N-heterocyclic carbene (NHC)-catalyzed oxidative γ-functionalization of α,β-unsaturated aldehydes bearing γ-H with isatin derivatives. The ready availability of the starting materials, easy work-up, mild reaction conditions and the potential utilization value of the products make this strategy attractive.