Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones.
Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones.
复制标题
DOI：
10.1016/j.bbamcr.2011.11.006
复制
发表时间：
2012-03
影响因子：
5.1
通讯作者：
Sanchez, Edwin R.
中科院分区：
文献类型：
--
作者：
Sanchez, Edwin R.
分子伴侣Hsp 90在真核生物中广泛存在，控制磷酸化级联反应、蛋白质稳定性和周转、客户端定位和运输以及配体-受体相互作用。毫不奇怪，Hsp 90并不单独完成这些活动。相反，越来越多的cochaperones已被确定，导致爆炸的报告，其分子和细胞的影响热休克蛋白90伴侣的客户基板。在这些患者中值得注意的是类固醇受体家族的许多成员，如糖皮质激素、雄激素、雌激素和孕酮受体。典型地与这些受体的成熟的、有表达能力的状态相关的辅伴侣包括p23、FK 506结合蛋白52（FKBP 52）、FKBP 51、蛋白磷酸酶5（PP 5）和亲环蛋白40（Cyp 40）。这些辅伴侣与类固醇受体作用的最终相关性取决于它们的生理效应。近年来，已经开发了这些辅伴侣的第一个小鼠遗传模型。这项工作将审查复杂和有趣的表型，迄今为止获得的基因改变小鼠和比较他们的已知分子和细胞的影响cochaperones类固醇受体。
The molecular chaperone Hsp90 is abundant, ubiquitous, and catholic to biological processes in eukaryotes, controlling phosphorylation cascades, protein stability and turnover, client localization and trafficking, and ligand-receptor interactions. Not surprisingly, Hsp90 does not accomplish these activities alone. Instead, an ever-growing number of cochaperones have been identified, leading to an explosion of reports on their molecular and cellular effects on Hsp90 chaperoning of client substrates. Notable among these clients are many members of the steroid receptor family, such as glucocorticoid, androgen, estrogen and progesterone receptors. Cochaperones typically associated with the mature, hormone-competent states of these receptors include p23, the FK506-binding protein 52 (FKBP52), FKBP51, protein phosphatase 5 (PP5) and cyclophilin 40 (Cyp40). The ultimate relevance of these cochaperones to steroid receptor action depend on their physiological effects. In recent years, the first mouse genetic models of these cochaperones have been developed. This work will review the complex and intriguing phenotypes so far obtained in genetically-altered mice and compare them to the known molecular and cellular impacts of cochaperones on steroid receptors.
登录
查看更多内容
影响因子：
5.3
作者：
Galigniana, Mario D.;Erlejman, Alejandra G.;Piwien-Pilipuk, Graciela
通讯作者：
Piwien-Pilipuk, Graciela
影响因子：
6.6
作者：
Febbo, PG;Lowenberg, M;Golub, TR
通讯作者：
Golub, TR
DOI：
10.1016/j.biocel.2004.03.013
发表时间：
2005-01-01
影响因子：
4
作者：
Davies, TH;Sánchez, ER
通讯作者：
Sánchez, ER
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
30.8
作者：
Binder, EB;Salyakina, D;Muller-Myhsok, B
通讯作者：
Muller-Myhsok, B