Effect of agmatine on food intake in mandarin fish (Siniperca chuatsi)
Effect of agmatine on food intake in mandarin fish (Siniperca chuatsi)
复制标题
胍丁胺对鳜鱼摄食量的影响
DOI：
10.1007/s10695-019-00659-w
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发表时间：
2019-05
影响因子：
2.9
通讯作者：
Shan He
中科院分区：
文献类型：
--
作者：
Liyuan Lv;Xu-Fang Liang;Kang Huang;Shan He
Agmatine, an endogenous biogenic amine, is considered to be a central neurotransmitter. And it plays an important role in mammal feeding behavior. However, there were few studies on the effect of agmatine on feeding behavior in fishes. Here, we investigated the impact of intracerebroventricular (ICV) injections of agmatine (1.25–20 nmol/fish) on food intake in mandarin fish (Siniperca chuatsi). At 1-h post-injection, food intake showed a significant decrease in agmatine-treated fishes compared with the saline treated. Furthermore, the food intake in agmatine treatment mostly did not differ from that in saline treatment at 4-–24-h post-injection as well as the results of genes expression of neuropeptide Y (NPY), agouti-regulated peptide (AgRP), and anorexigenic melanocortin 4 receptor (MC4R). In accordance with the insulin level increasing in liver, the gene expression of insulin receptor substrate (IRS2) was significantly higher in agmatine treatment compared to saline treatment at 1-h post-injection. Thus, the anorexigenic effect of agmatine is likely to decreaseNPYandAgRPexpression levels and increaseMC4RandIRS2levels which was coupled with stimulation of insulin secretion. Although these initial findings are limited in dose, the data firstly provides evidence for the anorectic effects of agmatine in fish.
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影响因子：
2.5
作者：
KALRA, SP;PEARSON, E;KALRA, PS
通讯作者：
KALRA, PS
影响因子：
1.2
作者：
Gorissen, Marnix H. A. G.;Flik, Gert;Huising, Mark O.
通讯作者：
Huising, Mark O.
影响因子：
64.8
作者：
WOODS, SC;LOTTER, EC;PORTE, D
通讯作者：
PORTE, D
DOI：
10.1172/jci24301
发表时间：
2005-04
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
Allison W. Xu;C. Kaelin;K. Takeda;S. Akira;M. Schwartz;G. Barsh
通讯作者：
Allison W. Xu;C. Kaelin;K. Takeda;S. Akira;M. Schwartz;G. Barsh
DOI：
10.1016/j.fct.2013.10.005
发表时间：
2013-12
期刊：
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
G. Gilad;V. Gilad
通讯作者：
G. Gilad;V. Gilad