Role of negative regulation of immune signaling pathways in neutrophil function.
Role of negative regulation of immune signaling pathways in neutrophil function.
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DOI：
10.1002/jlb.3mir0917-374r
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发表时间：
2017-12-19
影响因子：
5.5
通讯作者：
Brazil JC
中科院分区：
文献类型：
--
作者：
Azcutia V;Parkos CA;Brazil JC
多形核中性粒细胞（PMN）在宿主防御感染和解决炎症中发挥关键作用。然而，必须严格调节PMN介导的免疫反应，以促进消除入侵的病原体，而不引起有害的炎症和宿主组织损伤。多种细胞外信号对细胞表面免疫受体的特异性参与通过细胞内信号级联的差异激活来调节PMN效应的功能。虽然通过细胞信号通路介导的PMN激活机制已被很好地描述，但免疫信号级联对PMN功能的负调节知之甚少。在这里，我们概述了免疫受体介导的主要PMN效应功能的负调控，包括成熟、迁移、吞噬、ROS释放、脱颗粒、细胞凋亡和NETosis。对PMN效应功能抑制机制的进一步了解可能为改善PMN介导的自身免疫性和炎症性疾病指明未来可能的治疗靶点。免疫信号通路对PMN功能负调控的研究进展。
Polymorphonuclear neutrophils (PMN) play a critical role in host defense against infection and in the resolution of inflammation. However immune responses mediated by PMN must be tightly regulated to facilitate elimination of invading pathogens without inducing detrimental inflammation and host tissue damage. Specific engagement of cell surface immunoreceptors by a diverse range of extracellular signals regulates PMN effector functions through differential activation of intracellular signaling cascades. While mechanisms of PMN activation mediated via cell signaling pathways have been well described less is known about negative regulation of PMN function by immune signaling cascades. Here we provide an overview of immunoreceptor mediated negative regulation of key PMN effector functions including maturation, migration, phagocytosis, ROS release, degranulation, apoptosis and NETosis. Increased understanding of mechanisms of suppression of PMN effector functions may point to possible future therapeutic targets for the amelioration of PMN-mediated autoimmune and inflammatory diseases. Review on how PMN functions are negatively regulated by immune signaling pathways.