Susceptibility of Gardnerella vaginalis to metronidazole, its bioactive metabolites, and tinidazole.
Susceptibility of Gardnerella vaginalis to metronidazole, its bioactive metabolites, and tinidazole.
复制标题
阴道加德纳菌对甲硝唑、其生物活性代谢物和替硝唑的敏感性。
DOI：
10.1093/ajcp/87.5.640
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发表时间：
1987
影响因子：
3.5
通讯作者：
K. Biers
中科院分区：
文献类型：
--
作者：
R. Bannatyne;J. Jackowski;R. Cheung;K. Biers
The susceptibilities of 510 clinical isolates of Gardnerella vaginalis to metronidazole, its principal oxidative metabolites, and tinidazole were determined by an agar dilution method. The hydroxy metabolite was the most active, with an MIC90 value (minimum concentration that inhibited 90% of the strains) of 1.12 mg/L (5.51 mumol/L). Tinidazole and metronidazole were somewhat less active, with MIC90s of 4.09 mg/L (23.9 mumol/L) and 4.44 mg/L (18.0 mumol/L), respectively. The acid metabolite was inactive, with an MIC90 value of 226.55 mg/L (1.22 mmol/L). These results suggest that the hydroxy metabolite of metronidazole may contribute significantly to the antimicrobial effect of the parent drug in G. vaginalis-associated infections.
