Cortical Reorganization of Early Somatosensory Processing in Hemiparetic Stroke.
Cortical Reorganization of Early Somatosensory Processing in Hemiparetic Stroke.
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DOI：
10.3390/jcm11216449
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发表时间：
2022-10-31
影响因子：
3.9
通讯作者：
中科院分区：
文献类型：
--
作者：
脑卒中后皮层运动系统可以重组，对侧半球的活动增加。然而，在体感觉系统中是否发生类似的半球移位以适应这种运动变化，以及这是否与运动障碍有关，目前尚不清楚。这项概念验证研究评估了偏瘫卒中参与者和年龄匹配对照者在触觉手指刺激过程中使用高密度脑电图（EEG）记录的体感诱发电位（sep）， P50和N100。计算偏侧指数以确定SEP的半球优势，并通过源定位重新确认。研究发现，当刺激麻痹的手时，中风大脑中P50和N100的潜伏期明显延迟。对侧（受刺激手）脑半球P50振幅与脑卒中时fgl - meyer上肢运动评分呈负相关。在卒中中检测到双侧皮质反应，而在对照组中仅显示对侧皮质反应，导致侧度指数显着差异。这些结果表明，卒中后的体感觉重组涉及到同侧皮质区域的增加，特别是N100 SEP成分的增加。这种重组延缓了中风后体感处理的潜伏期。本研究提供了与脑卒中后体感觉重组相关的新见解，可以从感觉或感觉-运动的角度丰富未来假设驱动的治疗康复策略。
The cortical motor system can be reorganized following a stroke, with increased recruitment of the contralesional hemisphere. However, it is unknown whether a similar hemispheric shift occurs in the somatosensory system to adapt to this motor change, and whether this is related to movement impairments. This proof-of-concept study assessed somatosensory evoked potentials (SEPs), P50 and N100, in hemiparetic stroke participants and age-matched controls using high-density electroencephalograph (EEG) recordings during tactile finger stimulation. The laterality index was calculated to determine the hemispheric dominance of the SEP and re-confirmed with source localization. The study found that latencies of P50 and N100 were significantly delayed in stroke brains when stimulating the paretic hand. The amplitude of P50 in the contralateral (to stimulated hand) hemisphere was negatively correlated with the Fügl–Meyer upper extremity motor score in stroke. Bilateral cortical responses were detected in stroke, while only contralateral cortical responses were shown in controls, resulting in a significant difference in the laterality index. These results suggested that somatosensory reorganization after stroke involves increased recruitment of ipsilateral cortical regions, especially for the N100 SEP component. This reorganization delays the latency of somatosensory processing after a stroke. This research provided new insights related to the somatosensory reorganization after stroke, which could enrich future hypothesis-driven therapeutic rehabilitation strategies from a sensory or sensory-motor perspective.
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影响因子：
4.3
作者：
McPherson JG;Stienen AH;Drogos JM;Dewald JP
通讯作者：
Dewald JP
影响因子：
8.3
作者：
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影响因子：
3.4
作者：
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通讯作者：
Rymer, William Zev
影响因子：
4.2
作者：
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通讯作者：
Brass, Marcel
影响因子：
2.6
作者：
GALIN, D;ELLIS, RR
通讯作者：
ELLIS, RR