Association of LAPTM4B gene polymorphism with breast cancer susceptibility
Association of LAPTM4B gene polymorphism with breast cancer susceptibility
复制标题
LAPTM4B基因多态性与乳腺癌易感性的关系
DOI：
10.1016/j.canep.2011.12.004
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发表时间：
2012-08-01
影响因子：
2.6
通讯作者：
Zhang, Qingyun
中科院分区：
文献类型：
--
作者：
Fan, Meirong;Liu, Ye;Zhang, Qingyun
背景：溶酶体相关蛋白跨膜4 β (LAPTM4B)是一种与癌症相关的基因，定位于染色体8q22，具有7个外显子和6个内含子。据报道，LAPTM4B基因多态性与几种实体瘤的易感性显著相关。方法：采用病例对照研究，对732例乳腺癌患者和649例对照者进行LAPTM4B多态性与乳腺癌发病风险的相关性研究。结果：患者与对照组LAPTM4B*2频率差异有统计学意义（P < 0.01）。以LAPTM4B*1/1基因型为参照，我们发现LAPTM4B等位基因变异与乳腺癌发生显著相关，调整后比值比为1.387 (95% CI = 1.111 ~ 1.730)，调整后比值比为1.592 （95% CI = 1.043 ~ 2.430）。结论：我们的结果提示LAPTM4B* 2与中国女性乳腺癌风险增加相关，可能是乳腺癌的危险因素之一。(C) 2011 Elsevier Ltd.版权所有。
Background: Lysosome associated protein transmembrane 4 beta (LAPTM4B) was a cancer-associated gene that is mapped to chromosome 8q22 with seven exons and six introns. LAPTM4B gene polymorphism has been reported to be significantly associated with susceptibility of several solid tumors.Methods: We performed a case-control study was to investigate the association between LAPTM4B polymorphism and the risk of breast cancer in 732 breast cancer patients and 649 controls.Results: A significant difference in the frequency of LAPTM4B*2 was observed between the patients and the controls (P < 0.01). Using the LAPTM4B*1/1 genotype as a reference, we found that LAPTM4B allelic variation was significantly associated with breast cancer occurrence, with adjusted odds ratios of 1.387 (95% CI = 1.111-1.730) for LAPTM4B*1/2 and 1.592 (95% CI = 1.043-2.430) for LAPTM4B*2/2 genotype.Conclusion: Our results suggested that LAPTM4B* 2 is associated with an increased risk of breast cancer in the Chinese women population and may be a risk factor of breast cancer. (C) 2011 Elsevier Ltd. All rights reserved.