Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner
Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner
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DOI：
10.1016/j.ygeno.2007.01.003
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发表时间：
2007-05-01
期刊：
影响因子：
4.4
通讯作者：
Shiroishi, Toshibiko
中科院分区：
文献类型：
--
作者：
Tamura, Masaru;Tanaka, Shigekazu;Shiroishi, Toshibiko
Gasdermin(Gsdm)基因最初被认为是几种小鼠皮肤突变的候选致病基因。在小鼠和人类基因组中已经发现了几个与DFNA5具有相同蛋白结构域的Gsdm相关基因，DFNA5是人类非综合征性听力损失的致病基因，这组基因被称为DFNA5-Gasdermin结构域家族。然而，我们目前的比较基因组分析发现了几个新的基序，与以前报道的Gsdm相关基因中的结构域不同。我们还鉴定了三个新的Gsdm基因，这些基因聚集在小鼠的15号染色体上，我们将这些基因统称为Gsdm家族。广泛的表达分析表明，Gsdm家族基因以高度组织特异性的方式在皮肤和胃肠道上皮细胞中唯一表达。进一步的数据库搜索发现存在其他具有相似N-末端基序的相关基因。这些结果表明，Gsdm家族和相关基因进化出了不同的上皮表达谱。(C)2007 Elsevier Inc.保留所有权利。
Gasdermin (Gsdm) was originally identified as a candidate causative gene for several mouse skin mutants. Several Gsdm-related genes sharing a protein domain with DFNA5, the causative gene of human nonsyndromic hearing loss, have been found in the mouse and human genomes, and this group is referred to as the DFNA5-Gasdermin domain family. However, our current comparative genomic analysis identified several novel motifs distinct from the previously reported domain in the Gsdm-related genes. We also identified three new Gsdm genes clustered on mouse chromosome 15. We named these genes collectively the Gsdm family. Extensive expression analysis revealed exclusive expression of Gsdm family genes in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Further database searching revealed the presence of other related genes with a similar N-terminal motif. These results suggest that the Gsdm family and related genes have evolved divergent epithelial expression profiles. (c) 2007 Elsevier Inc. All rights reserved.