INTRACEREBROVENTRICULAR INJECTION OF BRAIN NATRIURETIC PEPTIDE INHIBITS VASOPRESSIN SECRETION IN CONSCIOUS RATS
INTRACEREBROVENTRICULAR INJECTION OF BRAIN NATRIURETIC PEPTIDE INHIBITS VASOPRESSIN SECRETION IN CONSCIOUS RATS
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DOI：
10.1016/0304-3940(88)90661-1
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发表时间：
1988-12-19
影响因子：
2.5
通讯作者：
IMURA, H
中科院分区：
文献类型：
--
作者：
YAMADA, T;NAKAO, K;IMURA, H
脑室内（i.c.v.）在清醒、无拘束的大鼠模型上，观察了注射猪脑肽（BNP）对精氨酸加压素（AVP）分泌的影响，并与心钠素（ANP）进行了比较。静脉注射BNP（0.01、0.1或1 nmol）可显著抑制基础AVP分泌，其作用与ANP相当。静脉注射血管紧张素II（0.1 nmol）诱导的AVP分泌被BNP（0.1或1 nmol）预处理显著抑制。这些结果表明，BNP参与AVP分泌的中枢控制，无论是单独或与脑ANP。
The effect of intracerebroventricular (i.c.v.) injection of brain natriurectic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.