Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants
Synthesis of the Bacteriocin Glycopeptide Sublancin 168 and S-Glycosylated Variants
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DOI：
10.1021/ol300557g
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发表时间：
2012-04-06
期刊：
影响因子：
5.2
通讯作者：
Payne, Richard J.
中科院分区：
文献类型：
--
作者：
Hsieh, Yves S. Y.;Wilkinson, Brendan L.;Payne, Richard J.
本文报道了一种独特的S-葡萄糖基化细菌素抗生素--亚兰菌素168的合成。天然产物和两个S-糖基化变体通过天然化学连接随后折叠成功制备。通过CD和NMR研究显示合成的糖肽主要具有α-螺旋二级结构。
The synthesis of sublancin 168, a unique S-glucosylated bacteriocin antibiotic, is described. The natural product and two S-glycosylated variants were successfully prepared via native chemical ligation followed by folding. The synthetic glycopeptides were shown to possess primarily an a-helical secondary structure by CD and NMR studies.