Unexpectedly high prevalence of akathisia in cancer patients
Unexpectedly high prevalence of akathisia in cancer patients
复制标题
癌症患者静坐不能的患病率出乎意料地高
DOI：
10.1017/s1478951507000545
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发表时间：
2007
影响因子：
2.2
通讯作者：
Y. Hirayasu
中科院分区：
文献类型：
--
作者：
C. Kawanishi;Hideki Onishi;D. Kato;I. Kishida;T. Furuno;M. Wada;Y. Hirayasu
摘要目的：在癌症患者中经常检测到神经精神障碍的并发症。适应障碍、抑郁或谵妄是这些患者常见的精神疾病，药物引起的神经精神问题有时会被转介到精神科会诊。据报告，丙氯拉嗪和其他吩噻嗪衍生物止吐药物也会因阻断中枢神经系统中的多巴胺受体而导致静坐不能，但尚未报告接受癌症治疗的患者中静坐不能的患病率。本研究旨在探讨此类药物诱导综合征的患病率（例如，在这一人群中。方法：本研究为前瞻性研究。本研究的受试者为2004年2月1日至2005年11月30日在神奈川县癌症中心精神科就诊的483名癌症患者。经过培训的精神科医生进行了非结构性精神病学访谈和神经系统检查，以根据DSM-IV和药物引起的锥体外系症状的存在或不存在建立精神病诊断。还详细检查了他们过去和目前在癌症治疗中使用的药物，以进行准确的评估。结果如下：483名癌症患者中有420名（87.0%）被诊断为精神病，静坐不能（一种药物引起的运动障碍）在患者中意外流行; 420名患者中有20名（4.8%）因止吐药丙氯拉嗪而出现静坐不能。结果的意义：由于癌症治疗中的复杂因素，诊断此类药物不良反应可能很困难，静坐不能中观察到的内心不安可能被视为原发性精神疾病的症状。作者建议，肿瘤学家应优化使用止吐药物，并意识到静坐不能是癌症治疗的可能并发症。
ABSTRACT Objectives: Complications of neuropsychiatric disorders are often detected in cancer patients. Adjustment disorders, depression, or delirium are common psychiatric disorders in these patients, and drug-induced neuropsychiatric problems are sometimes referred for psychiatric consultation. Prochlorperazine and other antiemetic drugs that are phenothiazine derivates are also reported to cause akathisia due to the blockade of the dopamine receptor in the central nervous system, but the prevalence of akathisia in patients undergoing cancer treatment has not been reported. This study seeks to explore the prevalence of such drug-induced syndromes (e.g., akathisia) in this population. Methods: This present study was a prospective study. The subjects of this study were 483 consecutive patients with cancer who had been referred to the Department of Psychiatry in Kanagawa Prefecture Cancer Center from February 1, 2004, to November 30, 2005. Trained psychiatrists conducted a nonstructured psychiatric interview and neurologic examination to establish psychiatric diagnoses according to DSM-IV and the presence or absence of drug-induced extra pyramidal symptoms. The past and current medications used in their cancer treatment were also examined in detail for an accurate evaluation. Results: A psychiatric diagnosis was made in 420 (87.0%) of the 483 cancer patients examined, and akathisia, a drug-induced movement disorder, was unexpectedly prevalent among the patients; 20 of 420 (4.8%) patients had developed akathisia from an antiemetic drug, prochlorperazine. Significance of results: Diagnosing such adverse drug reactions may be difficult due to complicating factors in cancer treatment, and the inner restlessness observed in akathisia is likely to be regarded as a symptom of a primary psychiatric disorder. The authors suggest that oncologists should optimize the use of antiemetic drugs and be aware of akathisia as a possible complication of cancer treatment.
癌症治疗中的抗精神病药物恶性综合征
DOI：
--
发表时间：
2005
期刊：
Palliative and Supportive Care 3
影响因子：
--
作者：
Kawanishi C;Onishi H;Kato D;et al.
通讯作者：
et al.