ROLE OF INTESTINAL GAS IN FUNCTIONAL ABDOMINAL-PAIN
ROLE OF INTESTINAL GAS IN FUNCTIONAL ABDOMINAL-PAIN
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DOI：
10.1056/nejm197509112931103
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
LEVITT, MD
中科院分区：
文献类型：
--
作者：
LASSER, RB;BOND, JH;LEVITT, MD
采用肠道输注惰性气体混合物的冲洗技术，研究气体与功能性腹部症状的关系。肠道气体体积（176 ± 28 ml S.E.M.）12例慢性胀气患者空腹血浆中的总胆汁酸（199 ± 31 ml）与10例对照组比较，差异无显著性（P > 0.10）。同样，肠道气体的组成或积聚速率也没有差异。然而，在输注对照组耐受良好的气体体积期间主诉腹痛的患者中，更多的气体倾向于回流到胃中。研究期间，6名重度疼痛患者的肠道气体通过时间（40 ±6分钟S.E.M.）与对照组（22 ± 3 min）比较，差异有统计学意义（P <0.05）。因此，腹胀、疼痛和胀气的主诉可能是由于肠蠕动紊乱以及对肠道扩张的异常疼痛反应，而不是由于气体体积增加。（《新英格兰医学杂志》293：524-526，1975）
A washout technic with intestinal infusion of an inert gas mixture was used to study the relation of gas to functional abdominal symptoms. The volume of gas in the intestinal tract (176 ± 28 ml S.E.M.) of 12 fasting patients with chronic complaints of excess gas did not differ significantly (P > 0.10) from that of 10 controls (199 ± 31 ml). Similarly, there was no difference in the composition or accumulation rate of intestinal gas. However, more gas tended to reflux back into the stomach in patients who complained of abdominal pain during infusion of volumes of gas well tolerated by controls. Six patients with severe pain during the study had intestinal transit times of gas (40 ±6 minutes S.E.M.) that were significantly (P <0.05) longer than those of the control group (22 ± 3 minutes). Thus, complaints of bloating, pain and gas may result from disordered intestinal motility in combination with an abnormal pain response to gut distention rather than from increased volumes of gas. (N Engl J Med 293:524–526, 1975)