Thymic alterations in Plasmodium berghei-infected mice
Thymic alterations in Plasmodium berghei-infected mice
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DOI：
10.1016/j.cellimm.2008.06.001
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发表时间：
2008-01-01
影响因子：
4.3
通讯作者：
Verinaud, L.
中科院分区：
文献类型：
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作者：
Andrade, C. F.;Gameiro, J.;Verinaud, L.
胸腺的主要功能是将未成熟的T细胞发育成细胞，进一步在外周将能够执行免疫功能。文献表明，胸腺可以是许多病原体的靶器官，在感染性疾病期间，该器官发生严重的结构改变。在这里，我们研究了胸腺是否也是实验性疟疾感染的靶器官，通过分析伯氏疟原虫NK 65感染的BALB/c小鼠胸腺内寄生虫的存在和组织学改变。感染14天后，在胸腺内发现寄生虫，胸腺严重萎缩，结构完全丧失。我们认为，寄生虫在胸腺中的存在会诱导组织学改变，改变微环境，从而损害成功的T细胞发育。我们的实验室目前正在开展更多的研究，以验证这种胸腺改变是否会影响对寄生虫的全身免疫反应。(C)2008年爱思唯尔公司All rights reserved.
The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we investigated if thymus is also a target organ during experimental malaria infection by analyzing the presence of parasites inside the organ and histological alterations in thymuses from Plasmodium berghei NK65-infected BALB/c. After 14 days of infection, parasites were found inside the thymus that presented a profound atrophy with total loss of its architecture. We propose that the presence of parasites in the thymus induces histological modifications that alter the microenvironment, impairing by consequence the successful T cell development. Additional studies are currently being developed in our laboratory to verify if such thymic alterations can influence the systemic immune response to the parasite. (C) 2008 Elsevier Inc. All rights reserved.