Mouse Model of Tuberculosis
Mouse Model of Tuberculosis
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DOI：
10.1101/cshperspect.a018556
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发表时间：
2015-02-01
影响因子：
5.4
通讯作者：
Cooper, Andrea M.
中科院分区：
文献类型：
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作者：
Cooper, Andrea M.
该小鼠提供了一种工具，用于探测哺乳动物免疫系统与生长缓慢、炎症性和持久性细菌结核分枝杆菌（Mtb）之间复杂的相互作用。使用基因缺失或抗体抑制的简单小鼠模型已经确定了免疫反应的特定成分与结核分枝杆菌攻击后存活之间的因果关系，这些研究与在人类中的观察结果相一致。为了改进目前的干预策略，有必要对介导和调节对结核分枝杆菌感染的保护性反应的免疫反应组成部分之间的复杂相互作用进行剖析；此外，特定分子和细胞的作用途径必须被描绘出来。鼠标模型提供了实现这一目标的工具；然而，实验设计和数据解释必须在整个结核病领域产生的数据集的背景下进行。
The mouse provides a tool with which to probe the complex interaction between the mammalian immune system and the slow-growing, inflammatory, and persistent bacterium, Mycobacterium tuberculosis (Mtb). Simple mouse models using genetic deletion or antibody inhibition have identified causal connections between specific components of the immune response and survival upon challenge with Mtb, and these studies have corresponded with observations made in humans. To improve on current intervention strategies, it is essential that the complex interactions between the components of the immune response that mediate and regulate the protective response to Mtb infection be dissected; furthermore, the pathways by which specific molecules and cells act must be delineated. The mouse model provides a tool with which to achieve this goal; however, experimental design and data interpretation must be made in the context of data sets generated from the entire tuberculosis field.