Nerve growth factor: role in growth, differentiation and controlling cancer cell development.
Nerve growth factor: role in growth, differentiation and controlling cancer cell development.
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DOI：
10.1186/s13046-016-0395-y
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发表时间：
2016-07-21
期刊：
影响因子：
--
通讯作者：
Micera A
中科院分区：
文献类型：
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作者：
Aloe L;Rocco ML;Balzamino BO;Micera A
神经生长因子（Nerve Growth Factor，NGF）研究的最新进展表明，该因子不仅作用于外周和中枢神经系统的经典区域外，而且作用于非神经元细胞和癌细胞。后一种观察结果导致了关于NGF的作用、其在组织内的特定分布模式及其在致癌作用的诱导和进展中的意义的不同假设。此外，其他最近的研究表明，NGF在某些人脑神经元变性和许多人类眼部疾病中具有直接的临床相关性。这些研究表明，神经生长因子参与了过多的生理功能，在健康和疾病，值得进一步调查的真正作用，神经生长因子在致癌作用。基于我们在NGF的生理病理学方面的长期经验，我们的目的是回顾以前和最近的在体内和体外研究肿瘤细胞的诱导，进展和逮捕。总之，这些研究表明，在正常神经元和非神经元细胞/组织中，仅存在NGF不能产生细胞致癌作用。然而，不能排除NGF和促癌分子共表达可能导致不同后果的可能性。在肿瘤发生过程中，神经生长因子是否在细胞增殖中起直接或间接的作用仍有待证实。
Recent progress in the Nerve Growth Factor (NGF) research has shown that this factor acts not only outside its classical domain of the peripheral and central nervous system, but also on non-neuronal and cancer cells. This latter observation has led to divergent hypothesis about the role of NGF, its specific distribution pattern within the tissues and its implication in induction as well as progression of carcinogenesis. Moreover, other recent studies have shown that NGF has direct clinical relevance in certain human brain neuron degeneration and a number of human ocular disorders. These studies, by suggesting that NGF is involved in a plethora of physiological function in health and disease, warrant further investigation regarding the true role of NGF in carcinogenesis. Based on our long-lasting experience in the physiopathology of NGF, we aimed to review previous and recent in vivo and in vitro NGF studies on tumor cell induction, progression and arrest. Overall, these studies indicate that the only presence of NGF is unable to generate cell carcinogenesis, both in normal neuronal and non-neuronal cells/tissues. However, it cannot be excluded the possibility that the co-expression of NGF and pro-carcinogenic molecules might open to different consequence. Whether NGF plays a direct or an indirect role in cell proliferation during carcinogenesis remains to demonstrate.